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Literature summary extracted from

  • Green, O.M.; McKenzie, A.R.; Shapiro, A.B.; Otterbein, L.; Ni, H.; Patten, A.; Stokes, S.; Albert, R.; Kawatkar, S.; Breed, J.
    Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series (2012), Bioorg. Med. Chem. Lett., 22, 1510-1519.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.157 purified GlmU, hanging drop vapour diffusion method, 20 mg/ml protein in 25 mM Tris–HCl, pH 7.5, 50 mM NaCl, 2 mM TCEP, is mixed with 2 mM inhibitor ligand, and incubated on ice for 30 min and centrifuged, then mixed with reservoir solution containing of 18-23% w/v PEG 3350, 200 mM ammonium sulfate and 100 mM PCTP, pH 7.0-8.0, 2-5 days, 20°C, X-ray diffraction structure determination and analysis Streptococcus pneumoniae
2.3.1.157 purified GlmU, hanging drop vapour diffusion method, mixing of 8 mg/ml enzyme in 50 mM Tris/HCl, pH 8.0, 150 mM NaCl, 2 mM EDTA, 2 mM TCEP, with 2 mM inhibitor ligand, and with reservoir solution containing 19–22% w/v PEG 3350 and either 100 mM PCTP, pH 5.0, 100-200 mM ammonium sulfate or 100 mM MMT, pH 6.0-7.0, and 400 mM ammonium sulfate, 20°C, 2-7 days, X-ray diffraction structure determination and analysis Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.157 (2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
-
 Escherichia coli
2.3.1.157 (2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
-
 Haemophilus influenzae
2.3.1.157 (2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
-
 Staphylococcus aureus
2.3.1.157 (2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
-
 Streptococcus pneumoniae
2.3.1.157 1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
-
 Escherichia coli
2.3.1.157 1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
-
 Haemophilus influenzae
2.3.1.157 1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
-
 Staphylococcus aureus
2.3.1.157 1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
-
 Streptococcus pneumoniae
2.3.1.157 2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
-
 Escherichia coli
2.3.1.157 2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
-
 Haemophilus influenzae
2.3.1.157 2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
-
 Staphylococcus aureus
2.3.1.157 2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
-
 Streptococcus pneumoniae
2.3.1.157 2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
-
 Escherichia coli
2.3.1.157 2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
-
 Haemophilus influenzae
2.3.1.157 2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
-
 Staphylococcus aureus
2.3.1.157 2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
-
 Streptococcus pneumoniae
2.3.1.157 4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
-
 Escherichia coli
2.3.1.157 4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
-
 Haemophilus influenzae
2.3.1.157 4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
-
 Staphylococcus aureus
2.3.1.157 4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
-
 Streptococcus pneumoniae
2.3.1.157 4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
-
 Escherichia coli
2.3.1.157 4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
-
 Haemophilus influenzae
2.3.1.157 4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
-
 Staphylococcus aureus
2.3.1.157 4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
-
 Streptococcus pneumoniae
2.3.1.157 4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
-
 Escherichia coli
2.3.1.157 4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
-
 Haemophilus influenzae
2.3.1.157 4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
-
 Staphylococcus aureus
2.3.1.157 4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
-
 Streptococcus pneumoniae
2.3.1.157 4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
-
 Escherichia coli
2.3.1.157 4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
-
 Haemophilus influenzae
2.3.1.157 4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
-
 Staphylococcus aureus
2.3.1.157 4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
-
 Streptococcus pneumoniae
2.3.1.157 4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
 Escherichia coli
2.3.1.157 4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
 Haemophilus influenzae
2.3.1.157 4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
 Staphylococcus aureus
2.3.1.157 4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
 Streptococcus pneumoniae
2.3.1.157 4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
 Escherichia coli
2.3.1.157 4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
 Haemophilus influenzae
2.3.1.157 4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
 Staphylococcus aureus
2.3.1.157 4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
-
 Streptococcus pneumoniae
2.3.1.157 methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
-
 Escherichia coli
2.3.1.157 methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
-
 Haemophilus influenzae
2.3.1.157 methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
-
 Staphylococcus aureus
2.3.1.157 methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
-
 Streptococcus pneumoniae
2.3.1.157 additional information high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series Escherichia coli
2.3.1.157 additional information high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series Haemophilus influenzae
2.3.1.157 additional information high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series Staphylococcus aureus
2.3.1.157 additional information high throughput inhibitor screening for inhibition of the acetyltransferase domain of GlmU by a arylsulfonamide series Streptococcus pneumoniae
2.3.1.157 N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
-
 Escherichia coli
2.3.1.157 N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
-
 Haemophilus influenzae
2.3.1.157 N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
-
 Staphylococcus aureus
2.3.1.157 N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
-
 Streptococcus pneumoniae
2.3.1.157 N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
-
 Escherichia coli
2.3.1.157 N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
-
 Haemophilus influenzae
2.3.1.157 N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
-
 Staphylococcus aureus
2.3.1.157 N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
-
 Streptococcus pneumoniae
2.3.1.157 N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
-
 Escherichia coli
2.3.1.157 N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
-
 Haemophilus influenzae
2.3.1.157 N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
-
 Staphylococcus aureus
2.3.1.157 N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
-
 Streptococcus pneumoniae
2.3.1.157 N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
-
 Escherichia coli
2.3.1.157 N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
-
 Haemophilus influenzae
2.3.1.157 N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
-
 Staphylococcus aureus
2.3.1.157 N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
-
 Escherichia coli
2.3.1.157 N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
-
 Haemophilus influenzae
2.3.1.157 N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
-
 Staphylococcus aureus
2.3.1.157 N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
-
 Escherichia coli
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
-
 Haemophilus influenzae
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
-
 Staphylococcus aureus
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer Escherichia coli
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer Haemophilus influenzae
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer Staphylococcus aureus
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide the inhibitor binds at the C-terminal domain of GlmU engaging the A, B and C subunits of the trimer Streptococcus pneumoniae
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
-
 Escherichia coli
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
-
 Haemophilus influenzae
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
-
 Staphylococcus aureus
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
-
 Escherichia coli
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
-
 Haemophilus influenzae
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
-
 Staphylococcus aureus
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
-
 Escherichia coli
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
-
 Haemophilus influenzae
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
-
 Staphylococcus aureus
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
-
 Escherichia coli
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
-
 Haemophilus influenzae
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
-
 Staphylococcus aureus
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
-
 Escherichia coli
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
-
 Haemophilus influenzae
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
-
 Staphylococcus aureus
2.3.1.157 N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
-
 Escherichia coli
2.3.1.157 N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
-
 Haemophilus influenzae
2.3.1.157 N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
-
 Staphylococcus aureus
2.3.1.157 N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
-
 Escherichia coli
2.3.1.157 N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
-
 Haemophilus influenzae
2.3.1.157 N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
-
 Staphylococcus aureus
2.3.1.157 N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
-
 Escherichia coli
2.3.1.157 N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
-
 Haemophilus influenzae
2.3.1.157 N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
-
 Staphylococcus aureus
2.3.1.157 N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
-
 Escherichia coli
2.3.1.157 N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
-
 Haemophilus influenzae
2.3.1.157 N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
-
 Staphylococcus aureus
2.3.1.157 N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
 Escherichia coli
2.3.1.157 N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
 Haemophilus influenzae
2.3.1.157 N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
 Staphylococcus aureus
2.3.1.157 N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
 Escherichia coli
2.3.1.157 N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
 Haemophilus influenzae
2.3.1.157 N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
 Staphylococcus aureus
2.3.1.157 N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Escherichia coli
2.3.1.157 N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Haemophilus influenzae
2.3.1.157 N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Staphylococcus aureus
2.3.1.157 N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Escherichia coli
2.3.1.157 N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Haemophilus influenzae
2.3.1.157 N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Staphylococcus aureus
2.3.1.157 N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Escherichia coli
2.3.1.157 N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Haemophilus influenzae
2.3.1.157 N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Staphylococcus aureus
2.3.1.157 N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Escherichia coli
2.3.1.157 N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Haemophilus influenzae
2.3.1.157 N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Staphylococcus aureus
2.3.1.157 N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Escherichia coli
2.3.1.157 N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Haemophilus influenzae
2.3.1.157 N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Staphylococcus aureus
2.3.1.157 N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Escherichia coli
2.3.1.157 N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Haemophilus influenzae
2.3.1.157 N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Staphylococcus aureus
2.3.1.157 N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Streptococcus pneumoniae
2.3.1.157 N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Escherichia coli
2.3.1.157 N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Haemophilus influenzae
2.3.1.157 N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Staphylococcus aureus
2.3.1.157 N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
-
 Streptococcus pneumoniae
2.3.1.157 [2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
-
 Escherichia coli
2.3.1.157 [2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
-
 Haemophilus influenzae
2.3.1.157 [2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
-
 Staphylococcus aureus
2.3.1.157 [2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
-
 Streptococcus pneumoniae
2.3.1.157 [[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
-
 Escherichia coli
2.3.1.157 [[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
-
 Haemophilus influenzae
2.3.1.157 [[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
-
 Staphylococcus aureus
2.3.1.157 [[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
-
 Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.157 acetyl-CoA + alpha-D-glucosamine 1-phosphate Staphylococcus aureus
-
 CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 ?
2.3.1.157 acetyl-CoA + alpha-D-glucosamine 1-phosphate Haemophilus influenzae
-
 CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 ?
2.3.1.157 acetyl-CoA + alpha-D-glucosamine 1-phosphate Escherichia coli
-
 CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 ?
2.3.1.157 acetyl-CoA + alpha-D-glucosamine 1-phosphate Streptococcus pneumoniae
-
 CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.157 Escherichia coli
-
-
-
2.3.1.157 Haemophilus influenzae
-
-
-
2.3.1.157 Staphylococcus aureus
-
-
-
2.3.1.157 Streptococcus pneumoniae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.157 acetyl-CoA + alpha-D-glucosamine 1-phosphate
-
 Staphylococcus aureus CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 ?
2.3.1.157 acetyl-CoA + alpha-D-glucosamine 1-phosphate
-
 Haemophilus influenzae CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 ?
2.3.1.157 acetyl-CoA + alpha-D-glucosamine 1-phosphate
-
 Escherichia coli CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 ?
2.3.1.157 acetyl-CoA + alpha-D-glucosamine 1-phosphate
-
 Streptococcus pneumoniae CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.157 heterotrimer
-
 Staphylococcus aureus
2.3.1.157 heterotrimer
-
 Haemophilus influenzae
2.3.1.157 heterotrimer
-
 Escherichia coli
2.3.1.157 heterotrimer
-
 Streptococcus pneumoniae

Synonyms

EC Number Synonyms Comment Organism
2.3.1.157 GlmU
-
 Staphylococcus aureus
2.3.1.157 GlmU
-
 Haemophilus influenzae
2.3.1.157 GlmU
-
 Escherichia coli
2.3.1.157 GlmU
-
 Streptococcus pneumoniae
2.3.1.157 N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase
-
 Staphylococcus aureus
2.3.1.157 N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase
-
 Haemophilus influenzae
2.3.1.157 N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase
-
 Escherichia coli
2.3.1.157 N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase
-
 Streptococcus pneumoniae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.157 22
-
 assay at romm temperature Staphylococcus aureus
2.3.1.157 22
-
 assay at romm temperature Haemophilus influenzae
2.3.1.157 22
-
 assay at romm temperature Escherichia coli
2.3.1.157 22
-
 assay at romm temperature Streptococcus pneumoniae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.157 7.3 7.4 assay at Staphylococcus aureus
2.3.1.157 7.3 7.4 assay at Haemophilus influenzae
2.3.1.157 7.3 7.4 assay at Escherichia coli
2.3.1.157 7.3 7.4 assay at Streptococcus pneumoniae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.157 0.00009
-
 pH 7.35, 22°C Escherichia coli 4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
2.3.1.157 0.0001
-
 pH 7.35, 22°C Escherichia coli [[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
2.3.1.157 0.0002
-
 pH 7.35, 22°C Haemophilus influenzae [[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
2.3.1.157 0.0002
-
 pH 7.35, 22°C Escherichia coli [2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
2.3.1.157 0.00025
-
 pH 7.35, 22°C Escherichia coli 4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
2.3.1.157 0.0003
-
 pH 7.35, 22°C Haemophilus influenzae [2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
2.3.1.157 0.0004
-
 pH 7.35, 22°C Escherichia coli 4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
2.3.1.157 0.0005
-
 pH 7.35, 22°C Escherichia coli N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
2.3.1.157 0.0005
-
 pH 7.35, 22°C Escherichia coli N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
2.3.1.157 0.0005
-
 pH 7.35, 22°C Escherichia coli (2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
2.3.1.157 0.0005
-
 pH 7.35, 22°C Haemophilus influenzae 4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
2.3.1.157 0.0005
-
 pH 7.35, 22°C Streptococcus pneumoniae 4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
2.3.1.157 0.0005
-
 pH 7.35, 22°C Escherichia coli 1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
2.3.1.157 0.0006
-
 pH 7.35, 22°C Haemophilus influenzae 4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
2.3.1.157 0.0009
-
 pH 7.35, 22°C Escherichia coli 2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
2.3.1.157 0.001
-
 pH 7.35, 22°C Haemophilus influenzae N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
2.3.1.157 0.001
-
 pH 7.35, 22°C Escherichia coli N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
2.3.1.157 0.001
-
 pH 7.35, 22°C Haemophilus influenzae 1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
2.3.1.157 0.0015
-
 pH 7.35, 22°C Escherichia coli N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
2.3.1.157 0.002
-
 pH 7.35, 22°C Escherichia coli N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
2.3.1.157 0.002
-
 pH 7.35, 22°C Haemophilus influenzae 2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
2.3.1.157 0.002
-
 pH 7.35, 22°C Escherichia coli 2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
2.3.1.157 0.002
-
 pH 7.35, 22°C Haemophilus influenzae (2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
2.3.1.157 0.002
-
 pH 7.35, 22°C Escherichia coli N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
2.3.1.157 0.002
-
 pH 7.35, 22°C Streptococcus pneumoniae 1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
2.3.1.157 0.002
-
 pH 7.35, 22°C Streptococcus pneumoniae 4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
2.3.1.157 0.003
-
 pH 7.35, 22°C Haemophilus influenzae N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
2.3.1.157 0.003
-
 pH 7.35, 22°C Escherichia coli N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
2.3.1.157 0.003
-
 pH 7.35, 22°C Escherichia coli 4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
2.3.1.157 0.003
-
 pH 7.35, 22°C Escherichia coli 4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
2.3.1.157 0.003
-
 pH 7.35, 22°C Haemophilus influenzae 4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
2.3.1.157 0.004
-
 pH 7.35, 22°C Escherichia coli N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.005
-
 pH 7.35, 22°C Haemophilus influenzae N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
2.3.1.157 0.005
-
 pH 7.35, 22°C Escherichia coli N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.005
-
 pH 7.35, 22°C Haemophilus influenzae 4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
2.3.1.157 0.005
-
 pH 7.35, 22°C Streptococcus pneumoniae 4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
2.3.1.157 0.005
-
 pH 7.35, 22°C Haemophilus influenzae 2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
2.3.1.157 0.006
-
 pH 7.35, 22°C Haemophilus influenzae N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
2.3.1.157 0.006
-
 pH 7.35, 22°C Haemophilus influenzae N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
2.3.1.157 0.006
-
 pH 7.35, 22°C Haemophilus influenzae 4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
2.3.1.157 0.008
-
 pH 7.35, 22°C Haemophilus influenzae N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
2.3.1.157 0.01
-
 pH 7.35, 22°C Streptococcus pneumoniae (2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
2.3.1.157 0.01
-
 pH 7.35, 22°C Haemophilus influenzae N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.01
-
 pH 7.35, 22°C Escherichia coli N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
2.3.1.157 0.01
-
 pH 7.35, 22°C Staphylococcus aureus 4-[[5-([2-[4-(carboxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
2.3.1.157 0.012
-
 pH 7.35, 22°C Streptococcus pneumoniae 4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
2.3.1.157 0.015
-
 pH 7.35, 22°C Escherichia coli N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.015
-
 pH 7.35, 22°C Escherichia coli N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.015
-
 pH 7.35, 22°C Escherichia coli methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
2.3.1.157 0.015
-
 pH 7.35, 22°C Streptococcus pneumoniae 2'-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]biphenyl-4-carboxylic acid
2.3.1.157 0.016
-
 pH 7.35, 22°C Haemophilus influenzae N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
2.3.1.157 0.017
-
 pH 7.35, 22°C Escherichia coli N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
2.3.1.157 0.02
-
 pH 7.35, 22°C Streptococcus pneumoniae N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
2.3.1.157 0.02
-
 pH 7.35, 22°C Streptococcus pneumoniae 4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
2.3.1.157 0.02
-
 pH 7.35, 22°C Escherichia coli N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
2.3.1.157 0.02
-
 pH 7.35, 22°C Haemophilus influenzae N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.021
-
 pH 7.35, 22°C Escherichia coli N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
2.3.1.157 0.025
-
 pH 7.35, 22°C Escherichia coli N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.03
-
 pH 7.35, 22°C Streptococcus pneumoniae N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
2.3.1.157 0.03
-
 pH 7.35, 22°C Haemophilus influenzae N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.04
-
 pH 7.35, 22°C Haemophilus influenzae N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
2.3.1.157 0.04
-
 pH 7.35, 22°C Escherichia coli N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.047
-
 pH 7.35, 22°C Haemophilus influenzae N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
2.3.1.157 0.05
-
 pH 7.35, 22°C Staphylococcus aureus 1-(2-[[([5-[(3-carboxypropanoyl)amino]-2,4-dimethoxyphenyl]sulfonyl)amino]methyl]phenyl)piperidine-4-carboxylic acid
2.3.1.157 0.055
-
 pH 7.35, 22°C Streptococcus pneumoniae N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
2.3.1.157 0.055
-
 pH 7.35, 22°C Haemophilus influenzae methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
2.3.1.157 0.06
-
 pH 7.35, 22°C Haemophilus influenzae N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.07
-
 pH 7.35, 22°C Haemophilus influenzae N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
2.3.1.157 0.07
-
 pH 7.35, 22°C Streptococcus pneumoniae N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.08
-
 pH 7.35, 22°C Haemophilus influenzae N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.08
-
 pH 7.35, 22°C Escherichia coli N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
2.3.1.157 0.08
-
 pH 7.35, 22°C Haemophilus influenzae N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.09
-
 pH 7.35, 22°C Streptococcus pneumoniae 2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
2.3.1.157 0.1
-
 pH 7.35, 22°C Escherichia coli N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
2.3.1.157 0.11
-
 pH 7.35, 22°C Streptococcus pneumoniae N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
2.3.1.157 0.12
-
 pH 7.35, 22°C Haemophilus influenzae N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
2.3.1.157 0.13
-
 pH 7.35, 22°C Escherichia coli N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[2,4-dimethoxy-5-[methyl(phenyl)sulfamoyl]phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[2,4-dimethoxy-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)sulfonyl]phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamothioyl)glycine
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]carbamoyl)glycine
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus 2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl acetate
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus (2E)-4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobut-2-enoic acid
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus 4-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-4-oxobutanoic acid
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus [[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae [[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethyl]sulfanyl]acetic acid
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]-2-(pyridin-4-ylsulfanyl)acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus 4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Haemophilus influenzae 4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Escherichia coli 4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae 4-[2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]benzoic acid
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Haemophilus influenzae N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]methanesulfonamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Haemophilus influenzae N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Escherichia coli N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]benzamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[2,4-dimethoxy-5-(phenylsulfamoyl)phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[2,4-dimethoxy-5-[phenyl(propan-2-yl)sulfamoyl]phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[5-[ethyl(2-methylphenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Haemophilus influenzae N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[5-[butyl(propan-2-yl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Haemophilus influenzae N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Haemophilus influenzae N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[2,4-dimethoxy-5-(piperidin-1-ylsulfonyl)phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Haemophilus influenzae N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Escherichia coli N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[5-(dimethylsulfamoyl)-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[5-[(4-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[5-[(3-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[5-[(2-fluorophenyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[2,4-dimethoxy-5-[(3-methylphenyl)sulfamoyl]phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[2,4-dimethoxy-5-[(4-methylphenyl)sulfamoyl]phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Haemophilus influenzae N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Escherichia coli N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[5-[(1,3-benzodioxol-5-ylmethyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae N-[5-[(2-bromobenzyl)sulfamoyl]-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Streptococcus pneumoniae methyl 2-[([[5-(acetylamino)-2,4-dimethoxyphenyl]sulfonyl]amino)methyl]benzoate
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Escherichia coli N-(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus N-[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]acetamide
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus 4-[(2,4-dimethoxy-5-[[2-(piperidin-1-yl)benzyl]sulfamoyl]phenyl)amino]-4-oxobutanoic acid
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus 4-[[5-([2-[4-(hydroxymethyl)piperidin-1-yl]benzyl]sulfamoyl)-2,4-dimethoxyphenyl]amino]-4-oxobutanoic acid
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus 4-[(5-[[2-(4-[[(carboxyacetyl)oxy]methyl]piperidin-1-yl)benzyl]sulfamoyl]-2,4-dimethoxyphenyl)amino]-4-oxobutanoic acid
2.3.1.157 0.2
-
 above, pH 7.35, 22°C Staphylococcus aureus [2-([2,4-dimethoxy-5-[(2-methyl-3,4-dihydroquinolin-1(2H)-yl)sulfonyl]phenyl]amino)-2-oxoethoxy]acetic acid
2.3.1.157 0.2
-
 pH 7.35, 22°C Escherichia coli N-[2,4-dimethoxy-5-[(2-methylpyrrolidin-1-yl)sulfonyl]phenyl]acetamide
2.3.1.157 0.54
-
 pH 7.35, 22°C Haemophilus influenzae N-[2,4-dimethoxy-5-[(2-methoxybenzyl)sulfamoyl]phenyl]acetamide

General Information

EC Number General Information Comment Organism
2.3.1.157 physiological function the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate Staphylococcus aureus
2.3.1.157 physiological function the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate Haemophilus influenzae
2.3.1.157 physiological function the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate Escherichia coli
2.3.1.157 physiological function the C-terminal domain of bifunctional GlmU catalyzes the transfer of an acetyl group from acetyl coenzyme A to glucosamine-1-phosphate to produce N-acetylglucosamine-1-phosphate. In the second step, the N-terminal domain of GlmU catalyzes the transfer of uridyl monophosphate from UTP to acetylglucosamine-1-phosphate to produce UDP-GlcNAc and diphosphate Streptococcus pneumoniae