EC Number | Cloned (Comment) | Organism |
---|---|---|
2.5.1.101 | gene lpg 0752, cloning and expression of NeuB results in insoluble protein which possesses very low levels of N,N'-diacetyllegionaminate synthase activity | Legionella pneumophila |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.101 | 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + phosphoenolpyruvate + H2O | Legionella pneumophila | - |
N,N'-diacetyllegionaminate + phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.101 | Legionella pneumophila | - |
serogroups 2-14, and strains Lansing 3 and 16453-92 from another serogroup, gene lpg 0752 or neuB homologue | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.101 | 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + phosphoenolpyruvate + H2O | - |
Legionella pneumophila | N,N'-diacetyllegionaminate + phosphate | - |
? | |
2.5.1.101 | 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose + phosphoenolpyruvate + H2O | - |
Legionella pneumophila | N,N'-diacetyllegionaminate + phosphate | i.e. Leg5Ac7Ac | ? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.5.1.101 | NeuB | - |
Legionella pneumophila |
2.5.1.101 | nonulosonic acid synthase | - |
Legionella pneumophila |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.5.1.101 | 37 | - |
assay at | Legionella pneumophila |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.5.1.101 | 7.5 | - |
assay at | Legionella pneumophila |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.5.1.101 | metabolism | the enzyme is involved in the the Leg pathway, which is essential for the biosynthesis of CMP-N,N'-diacetyllegionaminate, that acts as a donor substrate with a selection of bacterial and mammalian sialyltransferases | Legionella pneumophila |
2.5.1.101 | additional information | NeuB can be substituted by NanA from Escherichia coli, a sialic acid aldolase that catalyzes the condensation of 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose with pyruvate resulting in N,N'-diacetyllegionaminate formation, ability of sialyltransferases to utilize the CMP-N,N'-diacetyllegionaminate donor, overview | Legionella pneumophila |