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Literature summary extracted from

  • LaMarre, J.M.; Howden, B.P.; Mankin, A.S.
    Inactivation of the indigenous methyltransferase RlmN in Staphylococcus aureus increases linezolid resistance (2011), Antimicrob. Agents Chemother., 55, 2989-2991.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.192 gene rlmN Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.192 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA Staphylococcus aureus
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S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA
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?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.192 Staphylococcus aureus
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gene rlmN
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.192 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA
-
Staphylococcus aureus S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 2-methyladenine2503 in 23S rRNA
-
?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.192 RlmN
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Staphylococcus aureus

General Information

EC Number General Information Comment Organism
2.1.1.192 malfunction a naturally occurring rlmN mutation, by codon insertion in the rlmN gene, in a clinical Staphylococcus aureus isolate, strain JKD6229, decreases susceptibility to oxazolidinone antibiotic linezolid and is thought to increase the extent of A2503 modification, but mutation in fact abolishes RlmN activity, resulting in a lack of A2503 modification. rlmN knockout mutant Staphylococcus aureus Newman strain, SAV1218, shows a slight decrease in linezolid resistance, overview Staphylococcus aureus