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Literature summary extracted from

  • Miyazawa, M.; Shindo, M.; Shimada, T.
    Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes (2001), Xenobiotica, 31, 713-723.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.14.56 dexamethasone induces activity Rattus norvegicus
1.14.14.56 pregnenolone 16alpha-carbonitrile induces activity Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.56 expression in insect cells Homo sapiens
1.14.14.56 expression in insect cells Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.56 ketoconazole significant inhibition Homo sapiens
1.14.14.56 ketoconazole significant inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.14.56 0.45
-
 1,4-cineole pH 7.4, 37°C Homo sapiens
1.14.14.56 1.033
-
 1,4-cineole pH 7.4, 37°C, animals treated with pregnenolone 16alpha-carbonitrile Rattus norvegicus
1.14.14.56 1.123
-
 1,4-cineole pH 7.4, 37°C, animals treated with dexamethasone Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.56 Homo sapiens
-
-
-
1.14.14.56 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.56 1,4-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Homo sapiens 2-exo-hydroxy-1,4-cineole + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.56 1,4-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Rattus norvegicus 2-exo-hydroxy-1,4-cineole + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.56 1,8-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Homo sapiens 2-exo-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.56 1,8-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2
-
 Rattus norvegicus 2-exo-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.56 CYP3A4
-
 Homo sapiens