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Literature summary extracted from

  • Bastian, Y.; Roa-Espitia, A.; Mujica, A.; Hernandez-Gonzalez, E.
    Calpain modulates capacitation and acrosome reaction through cleavage of the spectrin cytoskeleton (2010), Reproduction, 140, 673-684.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.52 calpeptin complete inhibition at 0.5 mM Cavia porcellus
3.4.22.52 N-acetyl-Leu-Leu-Nle-CHO complete inhibition at 0.5 mM Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.52 cytoplasm calpain-1 is relocated and translocated from cytoplasm to plasma membrane during capacitation Cavia porcellus 5737
-
3.4.22.52 plasma membrane calpain-1 is relocated and translocated from cytoplasm to plasma membrane during capacitation Cavia porcellus 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.22.52 Ca2+ dependent on Cavia porcellus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.52 80000
-
 x * 80000, SDS-PAGE Cavia porcellus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.52 filamin-1 + H2O Cavia porcellus
-
 ?
-
 ?
3.4.22.52 spectrin + H2O Cavia porcellus
-
 ?
-
 ?
3.4.22.52 utrophin + H2O Cavia porcellus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.52 Cavia porcellus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.52 sperm
-
 Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.52 filamin-1 + H2O
-
 Cavia porcellus ?
-
 ?
3.4.22.52 spectrin + H2O
-
 Cavia porcellus ?
-
 ?
3.4.22.52 utrophin + H2O
-
 Cavia porcellus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.22.52 ? x * 80000, SDS-PAGE Cavia porcellus

General Information

EC Number General Information Comment Organism
3.4.22.52 physiological function calpain-1 inhibits the acrosome reaction and alters the plasma membrane-associated cytoskeleton in spermatozoa Cavia porcellus