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Literature summary extracted from

  • Martiญ, M.; Trotonda, M.; Tormo-Mas, M.; Vergara-Irigaray, M.; Cheung, A.; Lasa, I.; Penades, J.
    Extracellular proteases inhibit protein-dependent biofilm formation in Staphylococcus aureus (2010), Microbes Infect., 12, 55-64.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.29 extracellular the enzyme is secreted Staphylococcus aureus
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Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.29 additional information metalloprotease Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.29 Bap + H2O Staphylococcus aureus a surface-anchored protein ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.29 Staphylococcus aureus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.29 Bap + H2O a surface-anchored protein Staphylococcus aureus ?
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 ?

General Information

EC Number General Information Comment Organism
3.4.24.29 malfunction the sigB mutant strain overexpresses the surface-anchored protein Bap, that is essential for biofilm formation in the model strain. Staphylococcus aureus completely inhibits the biofilm formation of the mutant strain via Aur and SspA, two proteases that are overexpressed in the sigB mutant strain and are capable of degrading Bap Staphylococcus aureus
3.4.24.29 physiological function extracellular proteases Aur and SspA inhibit protein-dependent biofilm formation by Staphylococcus aureus, detailed overview Staphylococcus aureus