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Literature summary extracted from

  • White, J.; Beckford, J.; Yadegarynia, S.; Ngo, N.; Lialiutska, T.; DAlarcao, M.
    Some natural flavonoids are competitive inhibitors of caspase-1, -3, and -7 despite their cellular toxicity (2012), Food Chem., 131, 1453-1459.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.36 kaempferol
-
 Homo sapiens
3.4.22.36 luteolin
-
 Homo sapiens
3.4.22.36 myricetin
-
 Homo sapiens
3.4.22.36 quercetin
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.36 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.36 MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.36 Ac-LEHD-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Ac-LEHD + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.36 caspase-1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.22.36 30
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.22.36 0.014
-
 myricetin pH not specified in the publication, 30°C Homo sapiens
3.4.22.36 0.118
-
 luteolin pH not specified in the publication, 30°C Homo sapiens
3.4.22.36 0.3
-
 quercetin pH not specified in the publication, 30°C, value above Homo sapiens
3.4.22.36 0.3
-
 kaempferol pH not specified in the publication, 30°C, value above Homo sapiens