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Literature summary extracted from

  • Hallahan, D.; West, J.
    Cytochrome P-450 in plant/insect interactions: geraniol 10-hydroxylase and the biosynthesis of iridoid monoterpenoids (1995), Drug Metabol. Drug Interact., 12, 369-382.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.83 membrane
-
 Nepeta racemosa 16020
-
1.14.14.83 microsome
-
 Catharanthus roseus
-
-
1.14.14.83 microsome
-
 Nepeta racemosa
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.83 (R,S)-citronellol + [reduced NADPH-hemoprotein reductase] + O2 Catharanthus roseus
-
 (6E)-8-hydroxycitronellol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.83 (R,S)-citronellol + [reduced NADPH-hemoprotein reductase] + O2 Nepeta racemosa
-
 (6E)-8-hydroxycitronellol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.83 cis-nerol + [reduced NADPH-hemoprotein reductase] + O2 Catharanthus roseus
-
 (6E)-8-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.83 cis-nerol + [reduced NADPH-hemoprotein reductase] + O2 Nepeta racemosa
-
 (6E)-8-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.83 geraniol + [reduced NADPH-hemoprotein reductase] + O2 Catharanthus roseus
-
 (6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.83 geraniol + [reduced NADPH-hemoprotein reductase] + O2 Nepeta racemosa
-
 (6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.83 Catharanthus roseus
-
-
-
1.14.14.83 Nepeta racemosa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.83 leaf
-
 Catharanthus roseus
-
1.14.14.83 leaf
-
 Nepeta racemosa
-
1.14.14.83 seedling etiolated Nepeta racemosa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.83 (R,S)-citronellol + [reduced NADPH-hemoprotein reductase] + O2
-
 Catharanthus roseus (6E)-8-hydroxycitronellol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.83 (R,S)-citronellol + [reduced NADPH-hemoprotein reductase] + O2
-
 Nepeta racemosa (6E)-8-hydroxycitronellol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.83 (R,S)-citronellol + [reduced NADPH-hemoprotein reductase] + O2
-
 Catharanthus roseus (6E)-8-hydroxycitronellol + [oxidized NADPH-hemoprotein reductase] + H2O GC-MS product analysis ?
1.14.14.83 (R,S)-citronellol + [reduced NADPH-hemoprotein reductase] + O2
-
 Nepeta racemosa (6E)-8-hydroxycitronellol + [oxidized NADPH-hemoprotein reductase] + H2O GC-MS product analysis ?
1.14.14.83 cis-nerol + [reduced NADPH-hemoprotein reductase] + O2
-
 Catharanthus roseus (6E)-8-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.83 cis-nerol + [reduced NADPH-hemoprotein reductase] + O2
-
 Nepeta racemosa (6E)-8-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.83 cis-nerol + [reduced NADPH-hemoprotein reductase] + O2
-
 Catharanthus roseus (6E)-8-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O GC-MS product analysis ?
1.14.14.83 cis-nerol + [reduced NADPH-hemoprotein reductase] + O2
-
 Nepeta racemosa (6E)-8-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O GC-MS product analysis ?
1.14.14.83 geraniol + [reduced NADPH-hemoprotein reductase] + O2
-
 Catharanthus roseus (6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.83 geraniol + [reduced NADPH-hemoprotein reductase] + O2
-
 Nepeta racemosa (6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.83 geraniol + [reduced NADPH-hemoprotein reductase] + O2
-
 Catharanthus roseus (6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O GC-MS product analysis ?
1.14.14.83 geraniol + [reduced NADPH-hemoprotein reductase] + O2
-
 Nepeta racemosa (6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O GC-MS product analysis ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.83 G10H
-
 Catharanthus roseus
1.14.14.83 G10H
-
 Nepeta racemosa
1.14.14.83 geraniol 10-hydroxylase
-
 Catharanthus roseus
1.14.14.83 geraniol 10-hydroxylase
-
 Nepeta racemosa

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.83 cytochrome P450
-
 Catharanthus roseus
1.14.14.83 cytochrome P450
-
 Nepeta racemosa

General Information

EC Number General Information Comment Organism
1.14.14.83 evolution the enzyme is a cyt P450 monoterpene hydroxylase and belongs to the cytochrome-P450 monooxygenase family Catharanthus roseus
1.14.14.83 evolution the enzyme is a cyt P450 monoterpene hydroxylase and belongs to the cytochrome-P450 monooxygenase family Nepeta racemosa
1.14.14.83 metabolism the enzyme is involved in the biosynthesis of iridiod monoterpenoids Catharanthus roseus
1.14.14.83 metabolism the enzyme is involved in the biosynthesis of iridiod monoterpenoids Nepeta racemosa
1.14.14.83 physiological function the enzyme is involved in the biosynthesis of iridiod monoterpenoids, which are important in plant defense systems against herbivores Catharanthus roseus
1.14.14.83 physiological function the enzyme is involved in the biosynthesis of iridiod monoterpenoids, which are important in plant defense systems against herbivores Nepeta racemosa