EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.56 | (3beta,16alpha)-3-hydroxy-20-oxopregn-5-ene-16-carbonitrile | induces activity | Rattus norvegicus | |
1.14.14.56 | Phenobarbital | induces activity | Rattus norvegicus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.14.56 | expression in insect cells | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.56 | ketoconazole | significant inhibition | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.14.56 | 0.02 | - |
1,8-cineole | pH 7.4, 37°C, after treatment of animals with pregenolone-16alpha-carbonitrile | Rattus norvegicus | |
1.14.14.56 | 0.05 | - |
1,8-cineole | pH 7.4, 37°C | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.14.56 | microsome | - |
Rattus norvegicus | - |
- |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.56 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.14.56 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.56 | 1,8-cineole + [reduced NADPH-hemoprotein reductase] + H+ + O2 | - |
Rattus norvegicus | 2-exo-hydroxy-1,8-cineole + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.14.56 | CYP3A4 | - |
Rattus norvegicus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.14.14.56 | physiological function | CYP3A4 is a major enzyme involved in the oxidation of 1,8-cineole by human liver microsomes, as there is a good correlation between CYP3A4 contents and 1,8-cineole 2-hydroxylation activities in liver microsomes of eighteen human samples and of various recombinant human P450 enzymes examined, CYP3A4 has the highest activities for 1,8-cineole 2-hydroxylation | Rattus norvegicus |