EC Number | Organism | UniProt | Comment | Textmining |
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2.1.1.224 | Escherichia coli | - |
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EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
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2.1.1.224 | 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA | the newly introduced methyl group is assembled from an S-adenosyl-L-methionine (SAM)-derived methylene fragment and a hydrogen atom that had migrated from the substrate amidine carbon. Rather than activating the adenosine nucleotide of the substrate by hydrogen atom abstraction from an amidine carbon, the 5'-deoxyadenosyl radical abstracts hydrogen from the second equivalent of SAM to form the SAM-derived radical cation. This species, or its corresponding sulfur ylide, subsequently adds into the substrate, initiating hydride shift and S-adenosylhomocysteine elimination to complete the formation of the methyl group | Escherichia coli | S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA | - |
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EC Number | Synonyms | Comment | Organism |
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2.1.1.224 | Cfr | - |
Escherichia coli |