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Literature summary extracted from

  • Panosa, A.; Roca, I.; Gibert, I.
    Ribonucleotide reductases of Salmonella typhimurium: transcriptional regulation and differential role in pathogenesis (2010), PLoS ONE, 5, e11328.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.1 Salmonella enterica subsp. enterica serovar Typhimurium
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 serovar Typhimurium, inside RAW264.7 macrophages or HeLa cells
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1.17.4.2 Salmonella enterica subsp. enterica serovar Typhimurium
-
 serovar Typhimurium, inside RAW264.7 macrophages or HeLa cells
-

Synonyms

EC Number Synonyms Comment Organism
1.17.4.1 class Ib RNR
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 Salmonella enterica subsp. enterica serovar Typhimurium
1.17.4.2 class III RNR
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 Salmonella enterica subsp. enterica serovar Typhimurium

General Information

EC Number General Information Comment Organism
1.17.4.1 additional information transcriptional regulation of RNR classes as well as their differential function during infection of macrophage and epithelial cells, overview Salmonella enterica subsp. enterica serovar Typhimurium
1.17.4.1 physiological function role of RNRs during infection of macrophages and epithelial cells, overview. Class Ia to be mainly responsible for deoxyribonucleotide production during invasion and proliferation inside macrophages and epithelial cells, while class Ib RNR is not. Class Ib RNR may contribute to deoxyribonucleotide synthesis by means of both an NrdR and a Fur-dependent derepression of nrdHIEF due to hydrogen peroxide production and DNA damage associated with the oxidative burst, thus helping to overcome the host defenses Salmonella enterica subsp. enterica serovar Typhimurium
1.17.4.2 additional information transcriptional regulation of RNR classes as well as their differential function during infection of macrophage and epithelial cells, overview Salmonella enterica subsp. enterica serovar Typhimurium
1.17.4.2 physiological function role of RNRs during infection of macrophages and epithelial cells, overview. Class II RNR is not responsible for deoxyribonucleotide production during invasion and proliferation inside macrophages and epithelial cells Salmonella enterica subsp. enterica serovar Typhimurium