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Literature summary extracted from

  • Wang, Z.; Guhling, O.; Yao, R.; Li, F.; Yeats, T.H.; Rose, J.K.; Jetter, R.
    Two oxidosqualene cyclases responsible for biosynthesis of tomato fruit cuticular triterpenoids (2011), Plant Physiol., 155, 540-552.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.4.99.39 expressed in Saccharomyces cerevisiae mutant GIL77 Solanum lycopersicum
5.4.99.39 expressed in Saccharomyces cerevisiae mutant strain GIL77 Solanum lycopersicum
5.4.99.40 expressed in Saccharomyces cerevisiae mutant GIL77 Solanum lycopersicum
5.4.99.55 expressed in Saccharomyces cerevisiae strain GIL77 Solanum lycopersicum

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.39 Solanum lycopersicum
-
cultivars MicroTom, M82, and Ailsa Craig
-
5.4.99.39 Solanum lycopersicum E7DN63 variants M82, Ailsa Craig, and MicroTom
-
5.4.99.40 Solanum lycopersicum
-
cultivars MicroTom, M82, and Ailsa Craig
-
5.4.99.55 Solanum lycopersicum
-
cultivars MicroTom, M82 and Ailsa Craig
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.4.99.39 thin-layer chromatography Solanum lycopersicum
5.4.99.40 thin-layer chromatography Solanum lycopersicum

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.4.99.39 fruit
-
Solanum lycopersicum
-
5.4.99.40 fruit
-
Solanum lycopersicum
-
5.4.99.55 exocarp
-
Solanum lycopersicum
-
5.4.99.55 leaf
-
Solanum lycopersicum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.39 (3S)-2,3-epoxy-2,3-dihydrosqualene
-
Solanum lycopersicum beta-amyrin isoform SITT1 produces 13% beta-amyrin ?
5.4.99.39 (S)-2,3-oxidosqualene
-
Solanum lycopersicum beta-amyrin
-
?
5.4.99.40 (3S)-2,3-epoxy-2,3-dihydrosqualene
-
Solanum lycopersicum alpha-amyrin isoform SITT1 produces 18% alpha-amyrin ?
5.4.99.40 (S)-2,3-oxidosqualene
-
Solanum lycopersicum delta-amyrin + beta-amyrin + alpha-amyrin + multiflorenol + psi-taraxasterol + taraxasterol + ? isoform SITT1 produces 48% delta-amyrin, 13% beta-amyrin, 18% alpha-amyrin, and 3-7% each of multiflorenol, psi-taraxasterol, taraxasterol, and one unidentified triterpene alcohol isomer ?
5.4.99.55 (3S)-2,3-epoxy-2,3-dihydrosqualene
-
Solanum lycopersicum delta-amyrin the enzyme yields 48% delta-amyrin, 13% beta-amyrin, 18% alpha-amyrin, and 3% to 7% each of multiflorenol, C-taraxasterol, taraxasterol, and one unidentified triterpene alcohol isomer ?

Synonyms

EC Number Synonyms Comment Organism
5.4.99.39 multifunctional OSC
-
Solanum lycopersicum
5.4.99.39 SITTS1
-
Solanum lycopersicum
5.4.99.39 SlTTS1
-
Solanum lycopersicum
5.4.99.40 multifunctional OSC
-
Solanum lycopersicum
5.4.99.40 SlTTS1
-
Solanum lycopersicum
5.4.99.55 SlTTS2 SlTTS2 is a multifunctional oxidosqualene cyclase enzyme catalyzing the formation of seven different triterpenoid isomers Solanum lycopersicum