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Literature summary extracted from

  • Payne, R.J.; Bulloch, E.M.; Kerbarh, O.; Abell, C.
    Inhibition of chorismate-utilising enzymes by 2-amino-4-carboxypyridine and 4-carboxypyridone and 5-carboxypyridone analogues (2010), Org. Biomol. Chem., 8, 3534-3542.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.3.27 His-tagged veresion expressed in Escherichia coli C41(DE3) Serratia marcescens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.3.27 1-(1-carboxy-ethyl)-2-oxo-1,2-dihydro-pyridine-4-carboxylate
-
 Serratia marcescens
4.1.3.27 1-(1-carboxy-ethyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylate
-
 Serratia marcescens
4.1.3.27 1-(2-carboxy-allyl)-2-oxo-1,2-dihydro-pyridine-4-carboxylate
-
 Serratia marcescens
4.1.3.27 1-(2-carboxy-allyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylate
-
 Serratia marcescens
4.1.3.27 1-carboxymethyl -6-oxo-1,6-dihydro-pyridine-3-carboxylate
-
 Serratia marcescens
4.1.3.27 2-(1-carboxy-ethylamino)-isonicotinate
-
 Serratia marcescens
4.1.3.27 2-(carboxymethyl-amino)-isonicotinate
-
 Serratia marcescens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.3.27 0.0037
-
 chorismate pH 7.0, 25°C Serratia marcescens

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.27 Serratia marcescens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.3.27 immobilized metal ion affinity chromatography (Ni2+) Serratia marcescens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.3.27 chorismate + L-glutamine
-
 Serratia marcescens anthranilate + pyruvate + L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.3.27 anthranilate synthase
-
 Serratia marcescens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.1.3.27 5.6
-
 chorismate pH 7.0, 25°C Serratia marcescens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.3.27 0.0053
-
 1-(1-carboxy-ethyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylate pH 7.0, 25°C Serratia marcescens
4.1.3.27 0.041
-
 1-(1-carboxy-ethyl)-2-oxo-1,2-dihydro-pyridine-4-carboxylate pH 7.0, 25°C Serratia marcescens
4.1.3.27 0.05
-
 2-(1-carboxy-ethylamino)-isonicotinate pH 7.0, 25°C Serratia marcescens
4.1.3.27 0.059
-
 1-(2-carboxy-allyl)-2-oxo-1,2-dihydro-pyridine-4-carboxylate pH 7.0, 25°C Serratia marcescens
4.1.3.27 0.094
-
 2-(carboxymethyl-amino)-isonicotinate pH 7.0, 25°C Serratia marcescens
4.1.3.27 0.1
-
 1-carboxymethyl -6-oxo-1,6-dihydro-pyridine-3-carboxylate pH 7.0, 25°C Serratia marcescens
4.1.3.27 0.12
-
 1-(2-carboxy-allyl)-6-oxo-1,6-dihydro-pyridine-3-carboxylate pH 7.0, 25°C Serratia marcescens