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Literature summary extracted from

  • Viegas, S.C.; Silva, I.J.; Saramago, M.; Domingues, S.; Arraiano, C.M.
    Regulation of the small regulatory RNA MicA by ribonuclease III: a target-dependent pathway (2011), Nucleic Acids Res., 39, 2918-2930.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.26.3 lamB RNA MicA cleavage by RNase III is facilitated by base pairing with MicA mRNA target(s) Salmonella enterica subsp. enterica serovar Typhimurium
3.1.26.3 ompA RNA MicA cleavage by RNase III is facilitated by base pairing with MicA mRNA target(s) Salmonella enterica subsp. enterica serovar Typhimurium

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.26.3 RNase III in vitro transcription Salmonella enterica subsp. enterica serovar Typhimurium

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.26.3 Mg2+ required Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.26.3 additional information Salmonella enterica subsp. enterica serovar Typhimurium in vitro RNase III is active with MicA when it is in complex with its targets, ompA or lamB mRNAs. MicA is cleaved by RNase III in a coupled way with ompA mRNA ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.26.3 Salmonella enterica subsp. enterica serovar Typhimurium
-
 strain SL1344 and derivatives thereof
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.26.3 additional information in vitro RNase III is active with MicA when it is in complex with its targets, ompA or lamB mRNAs. MicA is cleaved by RNase III in a coupled way with ompA mRNA Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
3.1.26.3 additional information RNase III cleaves dsRNA Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.26.3 endoribonucleases III
-
 Salmonella enterica subsp. enterica serovar Typhimurium
3.1.26.3 ribonuclease III
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.26.3 37
-
 assay at Salmonella enterica subsp. enterica serovar Typhimurium

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.26.3 8
-
 assay at Salmonella enterica subsp. enterica serovar Typhimurium

General Information

EC Number General Information Comment Organism
3.1.26.3 additional information detection of MicA sense transcripts in an RNase III-deficient antisense mutant dependent on ompA Salmonella enterica subsp. enterica serovar Typhimurium
3.1.26.3 physiological function role of endoribonucleases III and E in Salmonella typhimurium sRNA MicA regulation, MicA is a trans-encoded small non-coding RNA, which downregulates porin-expression in stationaryphase. RNase III regulates MicA in a target-coupled way, while RNase E controls free MicA levels in the cell, mechanisms, overview. ompA expression is regulated by RNase III and is dependent on MicA, and degradation of both the sRNA MicA and the ompA target mRNA is dependent on RNase III Salmonella enterica subsp. enterica serovar Typhimurium