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Literature summary extracted from

  • Parveen, N.; Cornell, K.A.
    Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism (2011), Mol. Microbiol., 79, 7-20.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.2.2.9 medicine inhibitors of methylthioadenosine/S-adenosylhomocysteine nucleosidase are anti-infective drugs against various bacterial pathogens Escherichia coli
3.2.2.9 medicine inhibitors of MTA/SAH nucleosidase are anti-infective drugs against various bacterial pathogens Borreliella burgdorferi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.2.9 5'-deoxyadenosine + H2O Escherichia coli
-
 5-deoxy-D-ribose + adenine
-
 ?
3.2.2.9 5'-deoxyadenosine + H2O Borreliella burgdorferi
-
 5-deoxy-D-ribose + adenine
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O Escherichia coli
-
 5-methylthio-D-ribose + adenine
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O Borreliella burgdorferi
-
 5-methylthio-D-ribose + adenine
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O Escherichia coli
-
 S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O Borreliella burgdorferi
-
 S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.9 Borreliella burgdorferi
-
-
-
3.2.2.9 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.9 5'-deoxyadenosine + H2O
-
 Escherichia coli 5-deoxy-D-ribose + adenine
-
 ?
3.2.2.9 5'-deoxyadenosine + H2O
-
 Borreliella burgdorferi 5-deoxy-D-ribose + adenine
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O
-
 Escherichia coli 5-methylthio-D-ribose + adenine
-
 ?
3.2.2.9 5'-methylthioadenosine + H2O
-
 Borreliella burgdorferi 5-methylthio-D-ribose + adenine
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Escherichia coli S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
 ?
3.2.2.9 S-adenosyl-L-homocysteine + H2O
-
 Borreliella burgdorferi S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine
-
 ?

Subunits

EC Number Subunits Comment Organism
3.2.2.9 dimer
-
 Escherichia coli
3.2.2.9 dimer
-
 Borreliella burgdorferi

Synonyms

EC Number Synonyms Comment Organism
3.2.2.9 Bgp
-
 Borreliella burgdorferi
3.2.2.9 methylthioadenosine/S-adenosylhomocysteine nucleosidase
-
 Escherichia coli
3.2.2.9 methylthioadenosine/S-adenosylhomocysteine nucleosidase
-
 Borreliella burgdorferi
3.2.2.9 MTA/SAH nucleosidase
-
 Escherichia coli
3.2.2.9 MTA/SAH nucleosidase
-
 Borreliella burgdorferi
3.2.2.9 Pfs
-
 Escherichia coli
3.2.2.9 Pfs
-
 Borreliella burgdorferi

General Information

EC Number General Information Comment Organism
3.2.2.9 physiological function the enzyme is involved in the synthesis of 4,5-dihdroxy-2,3-pentanedione from methionine. S-adenosyl-L-homocysteine hydrolysis by MTA/SAH nucleosidase yields S-(5-deoxy-D-ribos-5-yl)-L-homocysteine, a precursor of autoinducer-2 synthesis, a quorum-sensing signal that governs a variety of bacterial phenotypes such as virulence and biofilm formation Escherichia coli
3.2.2.9 physiological function the enzyme is involved in the synthesis of 4,5-dihdroxy-2,3-pentanedione from methionine. S-adenosyl-L-homocysteine hydrolysis by MTA/SAH nucleosidase yields S-(5-deoxy-D-ribos-5-yl)-L-homocysteine, a precursor of autoinducer-2 synthesis, a quorum-sensing signal that governs a variety of bacterial phenotypes such as virulence and biofilm formation Borreliella burgdorferi