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Literature summary extracted from

  • Shepherd, M.; Sanguinetti, G.; Cook, G.M.; Poole, R.K.
    Compensations for diminished terminal oxidase activity in Escherichia coli: cytochrome bd-II-mediated respiration and glutamate metabolism (2010), J. Biol. Chem., 285, 18464-18472.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.10.3.11 Escherichia coli
-
-
-
1.10.3.11 Escherichia coli BW25113
-
-
-
7.1.1.3 Escherichia coli
-
-
-
7.1.1.3 Escherichia coli BW25113
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.10.3.11 ubiquinol + O2
-
Escherichia coli ubiquinone + H2O
-
?
1.10.3.11 ubiquinol + O2
-
Escherichia coli BW25113 ubiquinone + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.10.3.11 AppBC
-
Escherichia coli
1.10.3.11 cytochrome bd-II
-
Escherichia coli
7.1.1.3 AppBC
-
Escherichia coli
7.1.1.3 CydAB
-
Escherichia coli
7.1.1.3 cytochrome bd-I quinol oxidase
-
Escherichia coli
7.1.1.3 cytochrome bd-II quinol oxidase
-
Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.10.3.11 heme the enzyme contains a low spin heme b, high spin heme b, and heme d Escherichia coli
7.1.1.3 heme
-
Escherichia coli

Expression

EC Number Organism Comment Expression
1.10.3.11 Escherichia coli cytochrome bd-I-deficient Escherichia coli strain cydB has elevated levels of the AppBC cytochrome bd-II terminal oxidase up

General Information

EC Number General Information Comment Organism
1.10.3.11 physiological function AppBC alleviates the accumulation of electrons in the quinone pool during respiratory stress via electroneutral ubiquinol oxidation Escherichia coli
7.1.1.3 malfunction loss of cytochrome bd-I oxidase subunit II (gene cydB) causes diminished respiration rates, impaired motility and enhanced acid resistance. CydB cells contain elevated heme d, particularly at low pH. The GABA/glutamate gadC antiporter is highly up-regulated in cydB cells. Eschrichia coli can compensate for the loss of cytochrome bd-I activity Escherichia coli
7.1.1.3 physiological function cytochrome bd-II-mediated quinol oxidation prevents the accumulation of NADH, whereas GABA synthesis/antiport maintains the proton motive force for ATP production Escherichia coli