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Literature summary extracted from

  • Pelz, A.; Wieland, K.P.; Putzbach, K.; Hentschel, P.; Albert, K.; Götz, F.
    Structure and biosynthesis of staphyloxanthin from Staphylococcus aureus (2005), J. Biol. Chem., 280, 32493-32498.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.8.2
-
 Staphylococcus aureus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.B26 20300
-
 x * 20300, calculated Staphylococcus aureus
2.4.1.B54 42500
-
 x * 42500, calculated Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
1.3.8.2 Staphylococcus aureus O07855
-
-
2.3.1.B26 Staphylococcus aureus Q53588
-
-
2.3.1.B26 Staphylococcus aureus ATCC 25904 Q53588
-
-
2.4.1.B54 Staphylococcus aureus Q53590 member of the non-processive glycosyltransferase family
-
2.4.1.B54 Staphylococcus aureus ATCC 25904 Q53590 member of the non-processive glycosyltransferase family
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.B26 beta-D-glucosyl 4,4'-diaponeurosporenoate + palmitate
-
 Staphylococcus aureus [(6-O-palmitoyl)-beta-D-glucosyl] 4,4'-diaponeurosporenoate + H2O
-
 ?
2.3.1.B26 beta-D-glucosyl 4,4'-diaponeurosporenoate + palmitate
-
 Staphylococcus aureus ATCC 25904 [(6-O-palmitoyl)-beta-D-glucosyl] 4,4'-diaponeurosporenoate + H2O
-
 ?
2.3.1.B26 beta-D-glucosyl 4,4'-diaponeurosporenoic acid + 12-methyltetradecanoic acid enzyme esterifies glucose at the C6'' position with the carboxyl group of 12-methyltetradecanoic acid to yield staphyloxanthin Staphylococcus aureus staphyloxanthin + H2O i.e. beta-D-glucopyranosyl 1-O-(4,4'-diaponeurosporen-4-oate)-6-O-(12-methyltetradecanoate) ?
2.3.1.B26 beta-D-glucosyl 4,4'-diaponeurosporenoic acid + 12-methyltetradecanoic acid enzyme esterifies glucose at the C6'' position with the carboxyl group of 12-methyltetradecanoic acid to yield staphyloxanthin Staphylococcus aureus ATCC 25904 staphyloxanthin + H2O i.e. beta-D-glucopyranosyl 1-O-(4,4'-diaponeurosporen-4-oate)-6-O-(12-methyltetradecanoate) ?
2.3.1.B26 beta-D-glucosyl 4,4'-diaponeurosporenoic acid + myristate
-
 Staphylococcus aureus [(6-O-myristoyl)-beta-D-glucosyl] 4,4'-diaponeurosporenoate + H2O
-
 ?
2.3.1.B26 beta-D-glucosyl 4,4'-diaponeurosporenoic acid + myristate
-
 Staphylococcus aureus ATCC 25904 [(6-O-myristoyl)-beta-D-glucosyl] 4,4'-diaponeurosporenoate + H2O
-
 ?
2.4.1.B54 4,4'-diaponeurosporenoate + UDP-alpha-D-glucose enzyme esterifies glucose at the C1'' position with the carboxyl group of 4,4'-diaponeurosporenic acid to yield glucosyl 4,4'-diaponeurosporenoate Staphylococcus aureus glucosyl 4,4'-diaponeurosporenoate + UDP
-
 ?
2.4.1.B54 4,4'-diaponeurosporenoate + UDP-alpha-D-glucose enzyme esterifies glucose at the C1'' position with the carboxyl group of 4,4'-diaponeurosporenic acid to yield glucosyl 4,4'-diaponeurosporenoate Staphylococcus aureus ATCC 25904 glucosyl 4,4'-diaponeurosporenoate + UDP
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.B26 ? x * 20300, calculated Staphylococcus aureus
2.4.1.B54 ? x * 42500, calculated Staphylococcus aureus

Synonyms

EC Number Synonyms Comment Organism
1.3.8.2 CrtN
-
 Staphylococcus aureus
1.3.8.2 dehydrosqualene desaturase
-
 Staphylococcus aureus
2.3.1.B26 CrtO
-
 Staphylococcus aureus
2.3.1.B26 NWMN_2465 locus name Staphylococcus aureus
2.4.1.B54 CrtQ
-
 Staphylococcus aureus
2.4.1.B54 NWMN_2463 locus name Staphylococcus aureus

General Information

EC Number General Information Comment Organism
1.3.8.2 physiological function the enzyme is involved in the biosynthesis of the carotenoid staphyloxanthin Staphylococcus aureus
2.3.1.B26 physiological function expression of staphyloxanthin pathway genes crtO, crtP, crtQ, crtM and crtN in Staphylococcus carnosus results in synthesis staphyloxanthin. All five genes are necessary for staphyloxanthin biosynthesis Staphylococcus aureus
2.4.1.B54 physiological function expression of staphyloxanthin pathway genes crtP, crtQ, crtM and crtN in Staphylococcus carnosus results in synthesis of glucosyl 4,4'-diaponeurosporenoate as a major product, with minor amounts of 4,4'-diaponeurosporenoate Staphylococcus aureus