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Literature summary extracted from

  • Glas, A.; Kaya, E.; Schneider, S.; Heil, K.; Fazio, D.; Maul, M.; Carell, T.
    DNA (6-4) photolyases reduce dewar isomers for isomerization into (6-4) lesions (2010), J. Am. Chem. Soc., 132, 3254-3255.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.1.99.13 to study how the enzyme recognizes the T(6-4)C and T(Dew)C lesion analogues in the active site, DNA duplexes are crystallized together with the (6-4) photolyase Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
4.1.99.13 H365N mutant shows no repair activity Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
4.1.99.13 Drosophila melanogaster Q8SXK5
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
4.1.99.13 (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA) repair of Dewar valence isomers by (6-4) photolyases involves the rearrangement of the Dewar lesions into the corresponding (6-4) lesions. This reaction requires electron injection. (6-4) photolyases have two catalytic functions: Splitting (6-4) lesions and catalyzing the formal 4pi sigmatropic rearrangement of Dewar isomers to (6-4) lesions Drosophila melanogaster
a

Synonyms

EC Number Synonyms Comment Organism
4.1.99.13 (6-4) photolyase
-
 Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.99.13 FAD
-
 Drosophila melanogaster