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Literature summary extracted from

  • Hollmann, F.; Lin, P.C.; Witholt, B.; Schmid, A.
    Stereospecific biocatalytic epoxidation: the first example of direct regeneration of a FAD-dependent monooxygenase for catalysis (2003), J. Am. Chem. Soc., 125, 8209-8217.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.11 styrene + FADH2 + O2 Pseudomonas sp.
-
 (S)-2-phenyloxirane + FAD + H2O
-
 ?
1.14.14.11 styrene + FADH2 + O2 Pseudomonas sp. VLB120
-
 (S)-2-phenyloxirane + FAD + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.11 Pseudomonas sp.
-
-
-
1.14.14.11 Pseudomonas sp. VLB120
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.11 (1E)-prop-1-en-1-ylbenzene + FADH2 + O2
-
 Pseudomonas sp. (2R,3S)-2-methyl-3-phenyloxirane + FAD + H2O
-
 ?
1.14.14.11 (1E)-prop-1-en-1-ylbenzene + FADH2 + O2
-
 Pseudomonas sp. VLB120 (2R,3S)-2-methyl-3-phenyloxirane + FAD + H2O
-
 ?
1.14.14.11 1,2-dihydronaphthalene + FADH2 + O2
-
 Pseudomonas sp. (1R,2R)-1,2-dihydronaphthalene-1,2-diol + FAD + H2O
-
 ?
1.14.14.11 1,2-dihydronaphthalene + FADH2 + O2
-
 Pseudomonas sp. VLB120 (1R,2R)-1,2-dihydronaphthalene-1,2-diol + FAD + H2O
-
 ?
1.14.14.11 1H-indene + FADH2 + O2
-
 Pseudomonas sp. (1aS,6aR)-6,6a-dihydro-1aH-indeno[1,2-b]oxirene + FAD + H2O
-
 ?
1.14.14.11 1H-indene + FADH2 + O2
-
 Pseudomonas sp. VLB120 (1aS,6aR)-6,6a-dihydro-1aH-indeno[1,2-b]oxirene + FAD + H2O
-
 ?
1.14.14.11 3-chlorostyrene + FADH2 + O2
-
 Pseudomonas sp. (2S)-2-(3-chlorophenyl)oxirane + FAD + H2O
-
 ?
1.14.14.11 3-methylstyrene + FADH2 + O2
-
 Pseudomonas sp. (2S)-2-(3-methylphenyl)oxirane + FAD + H2O
-
 ?
1.14.14.11 4-bromostyrene + FADH2 + O2
-
 Pseudomonas sp. (2S)-2-(4-bromophenyl)oxirane + FAD + H2O
-
 ?
1.14.14.11 4-chlorostyrene + FADH2 + O2
-
 Pseudomonas sp. (2S)-2-(4-chlorophenyl)oxirane + FAD + H2O
-
 ?
1.14.14.11 4-fluorostyrene + FADH2 + O2
-
 Pseudomonas sp. (2S)-2-(4-fluorophenyl)oxirane + FAD + H2O
-
 ?
1.14.14.11 4-methylstyrene + FADH2 + O2
-
 Pseudomonas sp. (2S)-2-(4-methylphenyl)oxirane + FAD + H2O
-
 ?
1.14.14.11 styrene + FADH2 + O2
-
 Pseudomonas sp. (S)-2-phenyloxirane + FAD + H2O
-
 ?
1.14.14.11 styrene + FADH2 + O2 FADH2-dependent monooxygenase (in this case StyA) can be regenerated directly by means of non-native redox catalysts such as [Cp*Rh(bpy)-(H2O)]2+. This cell-free chemoenzymatic approach can be used for the production of enantiopure epoxides via asymmetric synthesis Pseudomonas sp. (S)-2-phenyloxirane + FAD + H2O
-
 ?
1.14.14.11 styrene + FADH2 + O2
-
 Pseudomonas sp. VLB120 (S)-2-phenyloxirane + FAD + H2O
-
 ?
1.14.14.11 styrene + FADH2 + O2 FADH2-dependent monooxygenase (in this case StyA) can be regenerated directly by means of non-native redox catalysts such as [Cp*Rh(bpy)-(H2O)]2+. This cell-free chemoenzymatic approach can be used for the production of enantiopure epoxides via asymmetric synthesis Pseudomonas sp. VLB120 (S)-2-phenyloxirane + FAD + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.11 StyA
-
 Pseudomonas sp.

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.11 FADH2 the enzyme is specific for FADH2. No activity with FADH2-dependent monooxygenase (in this case StyA) can be regenerated directly by means of non-native redox catalysts such as [Cp*Rh(bpy)-(H2O)]2+ Pseudomonas sp.