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Literature summary extracted from

  • Borrelli, S.; Zandberg, W.F.; Mohan, S.; Ko, M.; Martinez-Gutierrez, F.; Partha, S.K.; Sanders, D.A.; Av-Gay, Y.; Pinto, B.M.
    Antimycobacterial activity of UDP-galactopyranose mutase inhibitors (2010), Int. J. Antimicrob. Agents, 36, 364-368.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.99.9 (4-chlorophenyl)-[1-(4-chlorophenyl)-3-hydroxy-5-methyl-1H-pyrazol-4-yl]-methanone
-
Klebsiella pneumoniae
5.4.99.9 (4-chlorophenyl)-[1-(4-chlorophenyl)-3-hydroxy-5-methyl-1H-pyrazol-4-yl]-methanone
-
Mycobacterium tuberculosis
5.4.99.9 3-(4-iodophenyl)-2-[4-(3,4-dichlorophenyl)-thiazol-2-ylamino]-propionic acid
-
Klebsiella pneumoniae
5.4.99.9 3-(4-iodophenyl)-2-[4-(3,4-dichlorophenyl)-thiazol-2-ylamino]-propionic acid
-
Mycobacterium tuberculosis
5.4.99.9 ethambutol
-
Klebsiella pneumoniae
5.4.99.9 ethambutol
-
Mycobacterium tuberculosis
5.4.99.9 Quinine
-
Klebsiella pneumoniae
5.4.99.9 Quinine
-
Mycobacterium tuberculosis
5.4.99.9 UDP
-
Klebsiella pneumoniae
5.4.99.9 UDP
-
Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.9 Klebsiella pneumoniae
-
-
-
5.4.99.9 Mycobacterium tuberculosis
-
-
-
5.4.99.9 Mycobacterium tuberculosis H37Rv
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.9 UDP-D-galactopyranose
-
Klebsiella pneumoniae UDP-D-galactofuranose
-
?
5.4.99.9 UDP-D-galactopyranose
-
Mycobacterium tuberculosis UDP-D-galactofuranose
-
?
5.4.99.9 UDP-D-galactopyranose
-
Mycobacterium tuberculosis H37Rv UDP-D-galactofuranose
-
?

Synonyms

EC Number Synonyms Comment Organism
5.4.99.9 UGM
-
Klebsiella pneumoniae
5.4.99.9 UGM
-
Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
5.4.99.9 FAD
-
Klebsiella pneumoniae
5.4.99.9 FAD
-
Mycobacterium tuberculosis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.4.99.9 0.0072
-
pH and temperature not specified in the publication Klebsiella pneumoniae 3-(4-iodophenyl)-2-[4-(3,4-dichlorophenyl)-thiazol-2-ylamino]-propionic acid
5.4.99.9 0.037
-
pH and temperature not specified in the publication Mycobacterium tuberculosis 3-(4-iodophenyl)-2-[4-(3,4-dichlorophenyl)-thiazol-2-ylamino]-propionic acid
5.4.99.9 0.044
-
pH and temperature not specified in the publication Klebsiella pneumoniae (4-chlorophenyl)-[1-(4-chlorophenyl)-3-hydroxy-5-methyl-1H-pyrazol-4-yl]-methanone
5.4.99.9 0.062
-
pH and temperature not specified in the publication Mycobacterium tuberculosis (4-chlorophenyl)-[1-(4-chlorophenyl)-3-hydroxy-5-methyl-1H-pyrazol-4-yl]-methanone