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Literature summary extracted from

  • Satou, M.; Nishi, Y.; Yoh, J.; Hattori, Y.; Sugimoto, H.
    Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium (2010), Endocrinology, 151, 4765-4775.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.5 expressed in Escherichia coli BL21(DE3) cells Homo sapiens
3.1.1.5 expressed in Escherichia coli BL21(DE3) cells Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.5 D174A inactive Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.5 cytosol
-
 Homo sapiens 5829
-
3.1.1.5 cytosol
-
 Rattus norvegicus 5829
-
3.1.1.5 cytosol
-
 Bos taurus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.5 Bos taurus
-
-
-
3.1.1.5 Homo sapiens
-
-
-
3.1.1.5 Mus musculus Q9WTL7
-
-
3.1.1.5 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.5 Hep-G2 cell
-
 Homo sapiens
-
3.1.1.5 RAW-264.7 cell isoform lysophospholipase I only Mus musculus
-
3.1.1.5 serum
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.5 2-lysophosphatidylcholine + H2O
-
 Homo sapiens glycerophosphocholine + a carboxylate
-
 ?
3.1.1.5 2-lysophosphatidylcholine + H2O
-
 Rattus norvegicus glycerophosphocholine + a carboxylate
-
 ?
3.1.1.5 2-lysophosphatidylcholine + H2O
-
 Bos taurus glycerophosphocholine + a carboxylate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.5 acyl-protein thioesterase 1 exhibits deacylation activity as well as lysophospholipase activity in vitro Homo sapiens
3.1.1.5 acyl-protein thioesterase 1 exhibits deacylation activity as well as lysophospholipase activity in vitro Rattus norvegicus
3.1.1.5 acyl-protein thioesterase 1 exhibits deacylation activity as well as lysophospholipase activity in vitro Bos taurus
3.1.1.5 APT1 APT1 exhibits deacylation activity as well as lysophospholipase activity in vitro Homo sapiens
3.1.1.5 APT1 APT1 exhibits deacylation activity as well as lysophospholipase activity in vitro Rattus norvegicus
3.1.1.5 APT1 APT1 exhibits deacylation activity as well as lysophospholipase activity in vitro Bos taurus
3.1.1.5 lysophospholipase I isoform Homo sapiens
3.1.1.5 lysophospholipase I isoform Rattus norvegicus
3.1.1.5 lysophospholipase I isoform Bos taurus
3.1.1.5 lysophospholipase II isoform Homo sapiens
3.1.1.5 lysophospholipase II isoform Rattus norvegicus
3.1.1.5 lysophospholipase II isoform Bos taurus

Expression

EC Number Organism Comment Expression
3.1.1.5 Homo sapiens lipopolysaccharide suppresses APT1 mRNA and protein expression down
3.1.1.5 Rattus norvegicus lipopolysaccharide suppresses APT1 mRNA and protein expression down
3.1.1.5 Bos taurus lipopolysaccharide suppresses APT1 mRNA and protein expression down
3.1.1.5 Mus musculus APT1 is released at high levels from RAW264.7 macrophage-like cells into the culture medium after stimulation with lipopolysaccharide, the mRNA level of lysophospholipase II in RAW264.7 cells is much less than APT1 and not changed by lipopolysaccharide treatment up

General Information

EC Number General Information Comment Organism
3.1.1.5 physiological function the serum activity of APT1 plays an important role in determination of the concentration of des-acyl ghrelin in circulation, especially under septic inflammation Bos taurus