EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.4.12 | (1-aminodecane-1,1-diyl)bis(phosphonic acid) | a substrate analogue inhibitor of aSMase | Homo sapiens | |
3.1.4.12 | AD2765 | a substrate analogue inhibitor of aSMase | Homo sapiens | |
3.1.4.12 | alpha-mangostin | a xanthone from the bark of Garcinia speciosa | Homo sapiens | |
3.1.4.12 | amitriptyline | performs indirect inhibition of aSMase | Homo sapiens | |
3.1.4.12 | cowanin | a xanthone from the bark of Garcinia speciosa | Homo sapiens | |
3.1.4.12 | cowanol | a xanthone from the bark of Garcinia speciosa | Homo sapiens | |
3.1.4.12 | desipramine | performs indirect inhibition of aSMase | Homo sapiens | |
3.1.4.12 | imipramine | performs indirect inhibition of aSMase | Homo sapiens | |
3.1.4.12 | phosphatidyl inositol-3,5-bisphosphate | - |
Homo sapiens | |
3.1.4.12 | phosphatidylinositol-4,5-bisphosphate | - |
Homo sapiens | |
3.1.4.12 | SR33557 | the calcium channel inhibitor performs indirect inhibition of aSMase | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.1.4.12 | lysosome | - |
Homo sapiens | 5764 | - |
3.1.4.12 | additional information | the processed mature enzyme one portion of this enzyme is transported to the lysosomes and a second portion is secreted to extracytosolic side of the plasma membrane | Homo sapiens | - |
- |
3.1.4.12 | plasma membrane | extracytosolic side | Homo sapiens | 5886 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | a sphingomyelin + H2O | Homo sapiens | - |
a ceramide + choline phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.4.12 | Homo sapiens | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.1.4.12 | glycoprotein | synthesis of a 78 kDA preproform of the enzyme which is glycosylated and proteolytically cleaved to a 72 kDa pre-form and subsequently to a 70 kDA mature enzyme | Homo sapiens |
3.1.4.12 | proteolytic modification | synthesis of a 78 kDA preproform of the enzyme which is glycosylated and proteolytically cleaved to a 72 kDa pre-form and subsequently to a 70 kDA mature enzyme | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.4.12 | a sphingomyelin + H2O | - |
Homo sapiens | a ceramide + choline phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.4.12 | acid sphingomyelinase | - |
Homo sapiens |
3.1.4.12 | aSMase | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.1.4.12 | 0.0109 | - |
pH and temperature not specified in the publication | Homo sapiens | cowanol | |
3.1.4.12 | 0.014 | - |
pH and temperature not specified in the publication | Homo sapiens | alpha-mangostin | |
3.1.4.12 | 0.0192 | - |
pH and temperature not specified in the publication | Homo sapiens | cowanin | |
3.1.4.12 | 0.07 | - |
pH and temperature not specified in the publication | Homo sapiens | AD2765 |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.4.12 | malfunction | an inborn deficiency in aSMase activity leads to a lysosomal storage of sphingomyelin and a fatal pathology that has been designated as the type A and type B of Niemann-Pick-disease | Homo sapiens |
3.1.4.12 | additional information | besides the aSMase, an alkaline sphingomyelinase and two neutral sphingomyelinases 1 and 2, nSMase1 and nSMase2, exist | Homo sapiens |
3.1.4.12 | physiological function | aSMase is known to induce apoptosis in a variety of cell lines and is emerging as an important mediator of inflammation in various pathological backgrounds | Homo sapiens |