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Literature summary extracted from

  • Movahedzadeh, F.; Wheeler, P.R.; Dinadayala, P.; Av-Gay, Y.; Parish, T.; Daffe, M.; Stoker, N.G.
    Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis (2010), BMC Microbiol., 10, 50.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.3.25 genes impA and impC, genetic analysis of the four IMPase homologues that are present in the Mycobacterium tuberculosis genome, real-time quantitative PCR expression analysis Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
3.1.3.25 D86N site-directed mutagenesis of gene impC Mycobacterium tuberculosis
3.1.3.25 additional information construction of deletion mutants of genes impC and impA Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.3.25 inositol 1-phosphate + H2O Mycobacterium tuberculosis
-
 myo-inositol + phosphate
-
 ?
3.1.3.25 inositol 1-phosphate + H2O Mycobacterium tuberculosis H37Rv, ATCC 25618
-
 myo-inositol + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.25 Mycobacterium tuberculosis
-
 genes impA or Rv1604, and impC or Rv3137
-
3.1.3.25 Mycobacterium tuberculosis H37Rv, ATCC 25618
-
 genes impA or Rv1604, and impC or Rv3137
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.25 inositol 1-phosphate + H2O
-
 Mycobacterium tuberculosis myo-inositol + phosphate
-
 ?
3.1.3.25 inositol 1-phosphate + H2O
-
 Mycobacterium tuberculosis H37Rv, ATCC 25618 myo-inositol + phosphate
-
 ?
3.1.3.25 myo-inositol 1-phosphate + H2O
-
 Mycobacterium tuberculosis myo-inositol + phosphate
-
 ?
3.1.3.25 myo-inositol 1-phosphate + H2O
-
 Mycobacterium tuberculosis H37Rv, ATCC 25618 myo-inositol + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.25 IMPase
-
 Mycobacterium tuberculosis
3.1.3.25 inositol monophosphate phosphatase
-
 Mycobacterium tuberculosis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.3.25 37
-
 assay at Mycobacterium tuberculosis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.25 8
-
 assay at Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
3.1.3.25 physiological function Mycobacteria use inositol in phosphatidylinositol, for anchoring lipoarabinomannan, lipomannan, and phosphatidylinosotol mannosides in the cell envelope, and for the production of mycothiol, which maintains the redox balance of the cell. The protein encoded by gene impA is partly responsible for inositol synthesis, while the impC encoded protein is essential, overview Mycobacterium tuberculosis