EC Number | Cloned (Comment) | Organism |
---|---|---|
4.1.1.23 | - |
Staphylococcus aureus |
4.1.1.23 | - |
Homo sapiens |
4.1.1.23 | - |
Saccharomyces cerevisiae |
4.1.1.23 | - |
Methanothermobacter thermautotrophicus |
4.1.1.23 | - |
Helicobacter pylori |
4.1.1.23 | - |
Plasmodium falciparum |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
4.1.1.23 | hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with 4 and 10) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) | Saccharomyces cerevisiae |
4.1.1.23 | hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) | Staphylococcus aureus |
4.1.1.23 | hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) | Homo sapiens |
4.1.1.23 | hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) | Methanothermobacter thermautotrophicus |
4.1.1.23 | hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) | Helicobacter pylori |
4.1.1.23 | hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) | Plasmodium falciparum |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.23 | 5-cyano-UMP | poor inhibition | Helicobacter pylori | |
4.1.1.23 | 5-cyano-UMP | poor inhibition | Homo sapiens | |
4.1.1.23 | 5-cyano-UMP | poor inhibition | Methanothermobacter thermautotrophicus | |
4.1.1.23 | 5-cyano-UMP | poor inhibition | Plasmodium falciparum | |
4.1.1.23 | 5-cyano-UMP | poor inhibition | Saccharomyces cerevisiae | |
4.1.1.23 | 5-cyano-UMP | poor inhibition | Staphylococcus aureus | |
4.1.1.23 | barbiturate ribonucleoside 5'-monophosphate | very potent inhibitor | Helicobacter pylori | |
4.1.1.23 | barbiturate ribonucleoside 5'-monophosphate | very potent inhibitor | Homo sapiens | |
4.1.1.23 | barbiturate ribonucleoside 5'-monophosphate | very potent inhibitor | Methanothermobacter thermautotrophicus | |
4.1.1.23 | barbiturate ribonucleoside 5'-monophosphate | very potent inhibitor | Plasmodium falciparum | |
4.1.1.23 | barbiturate ribonucleoside 5'-monophosphate | very potent inhibitor | Saccharomyces cerevisiae | |
4.1.1.23 | barbiturate ribonucleoside 5'-monophosphate | very potent inhibitor | Staphylococcus aureus | |
4.1.1.23 | nifedipine | competitive inhibition | Helicobacter pylori | |
4.1.1.23 | nifedipine | competitive inhibition | Homo sapiens | |
4.1.1.23 | nifedipine | competitive inhibition | Methanothermobacter thermautotrophicus | |
4.1.1.23 | nifedipine | competitive inhibition | Plasmodium falciparum | |
4.1.1.23 | nifedipine | competitive inhibition | Saccharomyces cerevisiae | |
4.1.1.23 | nifedipine | competitive inhibition | Staphylococcus aureus | |
4.1.1.23 | nimodipine | competitive inhibition | Helicobacter pylori | |
4.1.1.23 | nimodipine | competitive inhibition | Homo sapiens | |
4.1.1.23 | nimodipine | competitive inhibition | Methanothermobacter thermautotrophicus | |
4.1.1.23 | nimodipine | competitive inhibition | Plasmodium falciparum | |
4.1.1.23 | nimodipine | competitive inhibition | Saccharomyces cerevisiae | |
4.1.1.23 | nimodipine | competitive inhibition | Staphylococcus aureus | |
4.1.1.23 | pyrazofurin | also known as pyrazomycin, potent inhibitor | Helicobacter pylori | |
4.1.1.23 | pyrazofurin | also known as pyrazomycin, potent inhibitor | Homo sapiens | |
4.1.1.23 | pyrazofurin | also known as pyrazomycin, potent inhibitor | Methanothermobacter thermautotrophicus | |
4.1.1.23 | pyrazofurin | also known as pyrazomycin, potent inhibitor | Plasmodium falciparum | |
4.1.1.23 | pyrazofurin | also known as pyrazomycin, potent inhibitor | Saccharomyces cerevisiae | |
4.1.1.23 | pyrazofurin | also known as pyrazomycin, potent inhibitor | Staphylococcus aureus | |
4.1.1.23 | pyrazofurin-5'-monophosphate | slow tight binding inhibitor | Helicobacter pylori | |
4.1.1.23 | pyrazofurin-5'-monophosphate | slow tight binding inhibitor | Homo sapiens | |
4.1.1.23 | pyrazofurin-5'-monophosphate | slow tight binding inhibitor | Methanothermobacter thermautotrophicus | |
4.1.1.23 | pyrazofurin-5'-monophosphate | slow tight binding inhibitor | Plasmodium falciparum | |
4.1.1.23 | pyrazofurin-5'-monophosphate | slow tight binding inhibitor | Saccharomyces cerevisiae | |
4.1.1.23 | pyrazofurin-5'-monophosphate | slow tight binding inhibitor | Staphylococcus aureus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.1.1.23 | 0.0017 | - |
orotidine 5'-phosphate | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Homo sapiens | |
4.1.1.23 | 0.0037 | - |
orotidine 5'-phosphate | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Methanothermobacter thermautotrophicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.1.1.23 | Helicobacter pylori | - |
- |
- |
4.1.1.23 | Homo sapiens | - |
- |
- |
4.1.1.23 | Methanothermobacter thermautotrophicus | - |
- |
- |
4.1.1.23 | Plasmodium falciparum | - |
- |
- |
4.1.1.23 | Saccharomyces cerevisiae | - |
- |
- |
4.1.1.23 | Staphylococcus aureus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
4.1.1.23 | - |
Staphylococcus aureus |
4.1.1.23 | - |
Homo sapiens |
4.1.1.23 | - |
Saccharomyces cerevisiae |
4.1.1.23 | - |
Methanothermobacter thermautotrophicus |
4.1.1.23 | - |
Helicobacter pylori |
4.1.1.23 | - |
Plasmodium falciparum |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.23 | Orotidine 5'-phosphate | - |
Staphylococcus aureus | UMP + CO2 | - |
? | |
4.1.1.23 | Orotidine 5'-phosphate | - |
Homo sapiens | UMP + CO2 | - |
? | |
4.1.1.23 | Orotidine 5'-phosphate | - |
Saccharomyces cerevisiae | UMP + CO2 | - |
? | |
4.1.1.23 | Orotidine 5'-phosphate | - |
Methanothermobacter thermautotrophicus | UMP + CO2 | - |
? | |
4.1.1.23 | Orotidine 5'-phosphate | - |
Helicobacter pylori | UMP + CO2 | - |
? | |
4.1.1.23 | Orotidine 5'-phosphate | - |
Plasmodium falciparum | UMP + CO2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.1.1.23 | ODCase | - |
Staphylococcus aureus |
4.1.1.23 | ODCase | - |
Homo sapiens |
4.1.1.23 | ODCase | - |
Saccharomyces cerevisiae |
4.1.1.23 | ODCase | - |
Methanothermobacter thermautotrophicus |
4.1.1.23 | ODCase | - |
Helicobacter pylori |
4.1.1.23 | ODCase | - |
Plasmodium falciparum |
4.1.1.23 | Orotidine-5'-monophosphate decarboxylase | - |
Staphylococcus aureus |
4.1.1.23 | Orotidine-5'-monophosphate decarboxylase | - |
Homo sapiens |
4.1.1.23 | Orotidine-5'-monophosphate decarboxylase | - |
Saccharomyces cerevisiae |
4.1.1.23 | Orotidine-5'-monophosphate decarboxylase | - |
Methanothermobacter thermautotrophicus |
4.1.1.23 | Orotidine-5'-monophosphate decarboxylase | - |
Helicobacter pylori |
4.1.1.23 | Orotidine-5'-monophosphate decarboxylase | - |
Plasmodium falciparum |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.1.1.23 | 0.000000009 | - |
barbiturate ribonucleoside 5'-monophosphate | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Saccharomyces cerevisiae | |
4.1.1.23 | 0.000005 | - |
pyrazofurin-5'-monophosphate | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Saccharomyces cerevisiae | |
4.1.1.23 | 0.000017 | - |
pyrazofurin-5'-monophosphate | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Homo sapiens | |
4.1.1.23 | 0.00013 | - |
pyrazofurin-5'-monophosphate | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Helicobacter pylori | |
4.1.1.23 | 0.0062 | - |
pyrazofurin-5'-monophosphate | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Methanothermobacter thermautotrophicus | |
4.1.1.23 | 9.1 | - |
5-cyano-UMP | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Plasmodium falciparum | |
4.1.1.23 | 290 | - |
5-cyano-UMP | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Helicobacter pylori | |
4.1.1.23 | 550 | - |
5-cyano-UMP | in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C | Staphylococcus aureus |