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Literature summary extracted from
- New function and application of the cysteine synthase from archaea (2010), Biochem. Eng. J., 48, 315-322.
No PubMed abstract available
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.22 | S-adenosyl-L-methionine | - |
Saccharomyces cerevisiae |  |
| 4.2.1.22 | S-adenosyl-L-methionine | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.22 | L-serine + L-homocysteine | Aeropyrum pernix | - |
L-cystathionine + H2O | - |
? | |
| 4.2.1.22 | L-serine + L-homocysteine | Saccharomyces cerevisiae | - |
L-cystathionine + H2O | - |
? | |
| 4.2.1.22 | L-serine + L-homocysteine | Homo sapiens | - |
L-cystathionine + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.22 | Aeropyrum pernix | Q9YCN5 | cystathionine beta-synthase | - |
| 4.2.1.22 | Homo sapiens | P35520 | - |
- |
| 4.2.1.22 | Saccharomyces cerevisiae | P32582 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.22 | L-serine + L-homocysteine | - |
Aeropyrum pernix | L-cystathionine + H2O | - |
? | |
| 4.2.1.22 | L-serine + L-homocysteine | - |
Saccharomyces cerevisiae | L-cystathionine + H2O | - |
? | |
| 4.2.1.22 | L-serine + L-homocysteine | - |
Homo sapiens | L-cystathionine + H2O | - |
? | |
| 4.2.1.22 | additional information | O-acetylserine sulfhydrylase isozyme A, OASSAp, EC 2.5.1.65, exhibits both O-acetylserine sulfhydrylase and cystathionine beta-synthase activities | Aeropyrum pernix | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.2.1.22 | multimer | - |
Saccharomyces cerevisiae |
| 4.2.1.22 | multimer | - |
Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.1.22 | CBS | - |
Aeropyrum pernix |
| 4.2.1.22 | CBS | - |
Saccharomyces cerevisiae |
| 4.2.1.22 | CBS | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.22 | heme | - |
Saccharomyces cerevisiae | |
| 4.2.1.22 | heme | - |
Homo sapiens | |
| 4.2.1.22 | pyridoxal 5'-phosphate | - |
Aeropyrum pernix | |
| 4.2.1.22 | pyridoxal 5'-phosphate | - |
Saccharomyces cerevisiae | |
| 4.2.1.22 | pyridoxal 5'-phosphate | - |
Homo sapiens | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 4.2.1.22 | metabolism | CBS is involved in the cysteine pathway of bacteria and plants, overview | Saccharomyces cerevisiae |
| 4.2.1.22 | metabolism | CBS is involved in the cysteine pathway of bacteria and plants, overview | Homo sapiens |
| 4.2.1.22 | metabolism | cystathionine beta-synthase is involved in the cysteine pathway of bacteria and plants, overview | Aeropyrum pernix |
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Release 2023.1 (January 2023)
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