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Literature summary extracted from

  • Bao, X.; Ogawa, T.; Se, S.; Akiyama, M.; Bahtiar, A.; Takeya, T.; Ishida-Kitagawa, N.
    Acid sphingomyelinase regulates osteoclastogenesis by modulating sphingosine kinases downstream of RANKL signaling (2011), Biochem. Biophys. Res. Commun., 405, 533-537.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.12 additional information generation of ASM knockdown cells by specific shRNA Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 bone marrow
-
 Mus musculus
-
3.1.4.12 macrophage
-
 Mus musculus
-
3.1.4.12 osteoclast
-
 Mus musculus
-
3.1.4.12 RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 a sphingomyelin + H2O
-
 Mus musculus a ceramide + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acid sphingomyelinase
-
 Mus musculus
3.1.4.12 ASM
-
 Mus musculus

Expression

EC Number Organism Comment Expression
3.1.4.12 Mus musculus ASM is NFAT2-inducible up

General Information

EC Number General Information Comment Organism
3.1.4.12 physiological function acid sphingomyelinase catalyzes the cleavage of sphingomyelin to generate ceramide. Ceramide levels may be a determining factor in osteoclast formation. As ceramide levels are also regulated by sphingosine kinase, as well as ASM. ASM differentially regulates sphingosine kinase 1 and sphingosine kinase 2 expression, the sphingosine kinases show opposing effects on osteoclast formation Mus musculus