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Literature summary extracted from

  • Kimura, M.; Kushiro, T.; Shibuya, M.; Ebizuka, Y.; Abe, I.
    Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase (2010), Biochem. Biophys. Res. Commun., 391, 899-902.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.4.99.7 expressed in Saccharomyces cerevisiae GIL77 cells Aspergillus fumigatus
5.4.99.32 expressed in Saccharomyces cerevisiae strain GIL77 Aspergillus fumigatus
5.4.99.47 expressed in Saccharomyces cerevisiae GIL77 cells Aspergillus fumigatus
5.4.99.47 expressed in Saccharomyces cerevisiae strain GIL77 Aspergillus fumigatus

Protein Variants

EC Number Protein Variants Comment Organism
5.4.99.7 additional information an oxidosqualene:protostadienol cyclase mutant in which the C-terminal residues 702APPGGMR708 are replaced with 702NKSCAIS708 efficiently produces a 1:1 mixture of lanosterol and parkeol Aspergillus fumigatus
5.4.99.32 additional information an OSPC mutant in which the C-terminal residues 702APPGGMR708 are replaced with 702NKSCAIS708, no longer produces the protostadienol, but instead efficiently produces a 1:1 mixture of lanosterol and parkeol (oxidosqualene:lanosterol cyclase activity) Aspergillus fumigatus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.4.99.32 membrane
-
Aspergillus fumigatus 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.4.99.32 83090
-
calculated from amino acid sequence Aspergillus fumigatus

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.7 Aspergillus fumigatus
-
-
-
5.4.99.32 Aspergillus fumigatus
-
-
-
5.4.99.47 Aspergillus fumigatus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.7 (3S)-squalene-2,3-epoxide
-
Aspergillus fumigatus lanosterol
-
?
5.4.99.32 (3S)-2,3-oxidosqualene
-
Aspergillus fumigatus protosta-17(20)Z,24-dien-3beta-ol + (20R)-protosta-13(17),24-dien-3beta-ol 3:1 product ratio ?
5.4.99.47 (3S)-2,3-oxidosqualene
-
Aspergillus fumigatus lanosterol + parkeol 1:1 product ratio ?
5.4.99.47 (3S)-2,3-oxidosqualene
-
Aspergillus fumigatus parkeol
-
?

Synonyms

EC Number Synonyms Comment Organism
5.4.99.7 ERG7
-
Aspergillus fumigatus
5.4.99.7 OSLC
-
Aspergillus fumigatus
5.4.99.7 oxidosqualene:lanosterol cyclase
-
Aspergillus fumigatus
5.4.99.32 OSC3
-
Aspergillus fumigatus
5.4.99.32 OSPC
-
Aspergillus fumigatus
5.4.99.32 oxidosqualene:protostadienol cyclase
-
Aspergillus fumigatus
5.4.99.47 ERG7
-
Aspergillus fumigatus
5.4.99.47 OSLC
-
Aspergillus fumigatus
5.4.99.47 OSPC oxidosqualene:protostadienol cyclase mutant in which the residues 702APPGGMR708 are replaced with the conserved 702NKSCAIS708 sequence Aspergillus fumigatus
5.4.99.47 oxidosqualene:lanosterol cyclase cf. EC 5.4.99.7 Aspergillus fumigatus