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Literature summary extracted from

  • Wu, H.; Ho, C.; Ko, T.; Popat, S.; Lin, C.; Wang, A.
    Structural basis of alpha-fucosidase inhibition by iminocyclitols with Ki values in the micro- to picomolar range (2010), Angew. Chem., 49, 337-340.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.63 (2R,3R,4R,5R,6S)-2-(aminomethyl)-6-methylpiperidine-3,4,5-triol
-
 Thermotoga maritima
3.2.1.63 (2R,3S,4S,5R,6S)-2-benzyl-6-methylpiperidine-3,4,5-triol
-
 Thermotoga maritima
3.2.1.63 (2S,3R,4S,5S,6R)-2-methyl-6-(propan-2-yl)piperidine-3,4,5-triol
-
 Thermotoga maritima
3.2.1.63 2-(1H-indol-3-yl)-N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]acetamide
-
 Thermotoga maritima
3.2.1.63 2-cyclopentyl-2-phenyl-N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]acetamide
-
 Thermotoga maritima
3.2.1.63 3-(1H-indol-3-yl)-N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]propanamide
-
 Thermotoga maritima
3.2.1.63 9-oxo-N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]-9H-fluorene-1-carboxamide
-
 Thermotoga maritima
3.2.1.63 N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]-1-benzofuran-2-carboxamide
-
 Thermotoga maritima
3.2.1.63 N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]-1H-indole-2-carboxamide
-
 Thermotoga maritima
3.2.1.63 N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]acetamide
-
 Thermotoga maritima

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.63 Thermotoga maritima Q9WYE2
-
-

Synonyms

EC Number Synonyms Comment Organism
3.2.1.63 alpha-fucosidase
-
 Thermotoga maritima

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.1.63 0.000000105
-
 3-(1H-indol-3-yl)-N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]propanamide pH and temperature not specified in the publication Thermotoga maritima
3.2.1.63 0.000000427
-
 N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]-1H-indole-2-carboxamide pH and temperature not specified in the publication Thermotoga maritima
3.2.1.63 0.000000441
-
 N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]-1-benzofuran-2-carboxamide pH and temperature not specified in the publication Thermotoga maritima
3.2.1.63 0.000000475
-
 2-(1H-indol-3-yl)-N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]acetamide pH and temperature not specified in the publication Thermotoga maritima
3.2.1.63 0.00000447
-
 N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]acetamide pH and temperature not specified in the publication Thermotoga maritima
3.2.1.63 0.0000163
-
 (2R,3R,4R,5R,6S)-2-(aminomethyl)-6-methylpiperidine-3,4,5-triol pH and temperature not specified in the publication Thermotoga maritima
3.2.1.63 0.001005
-
 2-cyclopentyl-2-phenyl-N-[[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-methylpiperidin-2-yl]methyl]acetamide pH and temperature not specified in the publication Thermotoga maritima
3.2.1.63 0.005
-
 (2R,3S,4S,5R,6S)-2-benzyl-6-methylpiperidine-3,4,5-triol pH and temperature not specified in the publication Thermotoga maritima
3.2.1.63 0.006
-
 (2S,3R,4S,5S,6R)-2-methyl-6-(propan-2-yl)piperidine-3,4,5-triol pH and temperature not specified in the publication Thermotoga maritima