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Literature summary extracted from

  • Dhandayuthapani, S.; Jagannath, C.; Nino, C.; Saikolappan, S.; Sasindran, S.J.
    Methionine sulfoxide reductase B (MsrB) of Mycobacterium smegmatis plays a limited role in resisting oxidative stress (2009), Tuberculosis, 89, S26-S32.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.4.12 expressed in Escherichia coli BL21(DE3) cells Mycolicibacterium smegmatis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.4.12 soluble
-
 Mycolicibacterium smegmatis
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.8.4.12 13300
-
 calculated from amino acid sequence Mycolicibacterium smegmatis
1.8.4.12 15000
-
 SDS-PAGE Mycolicibacterium smegmatis

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.12 Mycolicibacterium smegmatis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.12 L-methionine (R)-sulfoxide + thioredoxin
-
 Mycolicibacterium smegmatis L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.12 methionine sulfoxide reductase B
-
 Mycolicibacterium smegmatis
1.8.4.12 MsrB
-
 Mycolicibacterium smegmatis

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.12 thioredoxin
-
 Mycolicibacterium smegmatis

General Information

EC Number General Information Comment Organism
1.8.4.12 malfunction the msrB mutant MSDELTAmsrB exhibits significantly lower intracellular survival than its wild type counterpart and shows no sensitivity to oxidants in vitro. The msrA/B double mutant (MSDELTAmsrA/B) exhibits a phenotype similar to that of msrA mutant in terms of both intracellular survival and sensitivity to oxidants Mycolicibacterium smegmatis
1.8.4.12 physiological function MsrB of plays only a limited role in resisting intracellular and in vitro reactive oxygen intermediates Mycolicibacterium smegmatis