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Literature summary extracted from

  • Takahashi, T.; Miyazawa, M.
    Tyrosinase inhibitory activities of cinnamic acid analogues (2010), Pharmazie, 65, 913-918.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 3,4-dimethoxycinnamic acid 2.5% inhibition at 0.33 mM Agaricus bisporus
1.14.18.1 3,4-dimethoxydihydrocinnamic acid 20.2% inhibition at 1 mM Agaricus bisporus
1.14.18.1 4-coumaric acid 74.4% inhibition at 0.33 mM Agaricus bisporus
1.14.18.1 4-methoxycinnamic acid 55.2% inhibition at 1 mM Agaricus bisporus
1.14.18.1 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
-
 Agaricus bisporus
1.14.18.1 arbutin
-
 Agaricus bisporus
1.14.18.1 caffeic acid 6.6% inhibition at 1 mM Agaricus bisporus
1.14.18.1 Cinnamic acid 49.3% inhibition at 1 mM Agaricus bisporus
1.14.18.1 dihydro-4-coumaric acid 19.6% inhibition at 1 mM Agaricus bisporus
1.14.18.1 dihydro-4-methoxycinnamic acid 46.4% inhibition at 1 mM Agaricus bisporus
1.14.18.1 dihydrocaffeic acid 2.7% inhibition at 1 mM Agaricus bisporus
1.14.18.1 dihydrocinnamic acid 40.5% inhibition at 1 mM Agaricus bisporus
1.14.18.1 dihydroferulic acid 17.9% inhibition at 1 mM Agaricus bisporus
1.14.18.1 dihydroisoferulic acid 60.6% inhibition at 0.33 mM Agaricus bisporus
1.14.18.1 dihydrosinapic acid 22.6% inhibition at 1 mM Agaricus bisporus
1.14.18.1 ferulic acid 3.3% inhibition at 0.33 mM Agaricus bisporus
1.14.18.1 isoferulic acid 77.8% inhibition at 0.33 mM Agaricus bisporus
1.14.18.1 Sinapic acid 1.6% inhibition at 1 mM Agaricus bisporus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.18.1 L-DOPA + O2 Agaricus bisporus
-
 dopaquinone + H2O
-
 ?
1.14.18.1 L-tyrosine + O2 Agaricus bisporus
-
 L-DOPA + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-DOPA + O2
-
 Agaricus bisporus dopaquinone + H2O
-
 ?
1.14.18.1 L-tyrosine + O2
-
 Agaricus bisporus L-DOPA + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
 Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.0516
-
 in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
1.14.18.1 0.1149
-
 in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus isoferulic acid
1.14.18.1 0.1156
-
 in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus 4-coumaric acid
1.14.18.1 0.1957
-
 in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus dihydroisoferulic acid
1.14.18.1 0.2105
-
 in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus arbutin
1.14.18.1 0.8617
-
 in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus 4-methoxycinnamic acid
1.14.18.1 1
-
 IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus caffeic acid
1.14.18.1 1
-
 IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus ferulic acid
1.14.18.1 1
-
 IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus Cinnamic acid
1.14.18.1 1
-
 IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus Sinapic acid
1.14.18.1 1
-
 IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus 3,4-dimethoxycinnamic acid
1.14.18.1 1
-
 IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus dihydrocaffeic acid
1.14.18.1 1
-
 IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus dihydrocinnamic acid
1.14.18.1 1
-
 IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus dihydro-4-coumaric acid
1.14.18.1 1
-
 IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus dihydro-4-methoxycinnamic acid
1.14.18.1 1
-
 IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus dihydroferulic acid
1.14.18.1 1
-
 IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus 3,4-dimethoxydihydrocinnamic acid
1.14.18.1 1
-
 IC50 above 1.0 mM in 0.1 M phosphate buffer (pH 7.0), at 37°C Agaricus bisporus dihydrosinapic acid