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Literature summary extracted from

  • Nabekura, T.; Yamaki, T.; Hiroi, T.; Ueno, K.; Kitagawa, S.
    Inhibition of anticancer drug efflux transporter P-glycoprotein by rosemary phytochemicals (2010), Pharmacol. Res., 61, 259-263.
    View publication on PubMed

Application

EC Number Application Comment Organism
7.6.2.2 medicine rosemary phytochemicals, such as carnosic acid, have inhibitory effects on anticancer drug efflux transporter P-glycoprotein and may become useful to enhance the efficacy of cancer chemotherapy Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.2 carnosic acid increases the accumulation of daunorubicin or rhodamine 123 in KB-C2 cells. The ATPase activity of P-glycoprotein is stimulated Homo sapiens
7.6.2.2 carnosol increases the accumulation of daunorubicin or rhodamine 123 in KB-C2 cells. The ATPase activity of P-glycoprotein is stimulated Homo sapiens
7.6.2.2 ursolic acid increases the accumulation of daunorubicin or rhodamine 123 in KB-C2 cells. The ATPase activity of P-glycoprotein is stimulated Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.2 KB-C2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 ATP + H2O + daunorubicin/in
-
 Homo sapiens ADP + phosphate + daunorubicin/out
-
 ?
7.6.2.2 ATP + H2O + rhodamine 123/in
-
 Homo sapiens ADP + phosphate + rhodamine 123/out
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.2 ABCB1
-
 Homo sapiens
7.6.2.2 MDR1
-
 Homo sapiens
7.6.2.2 P-glycoprotein
-
 Homo sapiens