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Literature summary extracted from
- Na+/K+-ATPase inhibition by ouabain induces CaMKII-dependent apoptosis in adult rat cardiac myocytes (2010), J. Mol. Cell. Cardiol., 49, 459-468.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 7.2.2.13 | medicine | the positive inotropic effect produced by Na+/K+-ATPase inhibition is used for the treatment of heart failure | Mus musculus |
| 7.2.2.13 | medicine | the positive inotropic effect produced by Na+/K+-ATPase inhibition is used for the treatment of heart failure | Rattus norvegicus |
| 7.2.2.13 | medicine | the positive inotropic effect produced by Na+/K+-ATPase inhibition is used for the treatment of heart failure | Felis catus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.13 | Ouabain | ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis. The NCX inhibitor KB-R7943 and by the CaMKII inhibitors, KN93 and AIP prevent ouabain-induced apoptosis without affecting inotropy. Ouabain produces in the cat at 25 nM a 43% decrease in cell viability due to apoptosis and necrosis | Felis catus |  |
| 7.2.2.13 | Ouabain | ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis.The NCX inhibitor KB-R7943 and by the CaMKII inhibitors, KN93 and AIP prevent ouabain-induced apoptosis without affecting inotropy | Mus musculus | |
| 7.2.2.13 | Ouabain | ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis. The NCX inhibitor KB-R7943 and by the CaMKII inhibitors, KN93 and AIP prevent ouabain-induced apoptosis without affecting inotropy. Ouabain produces in the rat at 0.002 mM a 43% decrease in cell viability due to apoptosis and necrosis | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.2.2.13 | membrane | - |
Mus musculus | 16020 | - |
| 7.2.2.13 | membrane | - |
Rattus norvegicus | 16020 | - |
| 7.2.2.13 | membrane | - |
Felis catus | 16020 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.13 | ATP + H2O + Na+/in + K+/out | Mus musculus | - |
ADP + phosphate + Na+/out + K+/in | - |
? | |
| 7.2.2.13 | ATP + H2O + Na+/in + K+/out | Rattus norvegicus | - |
ADP + phosphate + Na+/out + K+/in | - |
? | |
| 7.2.2.13 | ATP + H2O + Na+/in + K+/out | Felis catus | - |
ADP + phosphate + Na+/out + K+/in | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.2.13 | Felis catus | - |
- |
- |
| 7.2.2.13 | Mus musculus | - |
- |
- |
| 7.2.2.13 | Rattus norvegicus | - |
Wistar rats | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 7.2.2.13 | cardiac myocyte | - |
Mus musculus | - |
| 7.2.2.13 | cardiac myocyte | - |
Rattus norvegicus | - |
| 7.2.2.13 | cardiac myocyte | - |
Felis catus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.13 | ATP + H2O + Na+/in + K+/out | - |
Mus musculus | ADP + phosphate + Na+/out + K+/in | - |
? | |
| 7.2.2.13 | ATP + H2O + Na+/in + K+/out | - |
Rattus norvegicus | ADP + phosphate + Na+/out + K+/in | - |
? | |
| 7.2.2.13 | ATP + H2O + Na+/in + K+/out | - |
Felis catus | ADP + phosphate + Na+/out + K+/in | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.2.2.13 | Na+/K+-ATPase | - |
Mus musculus |
| 7.2.2.13 | Na+/K+-ATPase | - |
Rattus norvegicus |
| 7.2.2.13 | Na+/K+-ATPase | - |
Felis catus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 7.2.2.13 | additional information | Na+,K+-ATPase inhibitor ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis. KN93 prevents ouabain-induced apoptosis without affecting inotropy | Mus musculus |
| 7.2.2.13 | additional information | Na+,K+-ATPase inhibitor ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis. KN93 prevents ouabain-induced apoptosis without affecting inotropy | Rattus norvegicus |
| 7.2.2.13 | additional information | Na+,K+-ATPase inhibitor ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis. KN93 prevents ouabain-induced apoptosis without affecting inotropy | Felis catus |
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