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Literature summary extracted from

  • Tandogan, B.; Ulusu, N.N.
    Inhibition of purified bovine liver glutathione reductase with some metal ions (2010), J. Enzyme Inhib. Med. Chem., 25, 68-73.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 Cd2+ non-competitive inhibition with respect to both NADPH and GSSG Bos taurus
1.8.1.7 additional information glutathione reductase is not influenced by Al3+, Ba2+, Mn2+, and Li+ at 0.01-0.1 mM, and by Ca2+ and Mo6+ at 0.005-0.125 mM Bos taurus
1.8.1.7 Ni2+ non-competitive inhibition with respect to GSSG and uncompetitive inhibition with respect to NADPH Bos taurus
1.8.1.7 Zn2+ non-competitive inhibition with respect to both NADPH and GSSG Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.7 liver
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 GSSG + NADPH + H+
-
 Bos taurus glutathione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.7 EC 1.6.4.2 formerly Bos taurus
1.8.1.7 glutathione reductase
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.7 FAD
-
 Bos taurus
1.8.1.7 NADPH
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.8.1.7 0.113
-
 Cd2+ with NADPH as the varied substrate, pH 7.4, 37°C Bos taurus
1.8.1.7 0.221
-
 Cd2+ with GSSG as the varied substrate, pH 7.4, 37°C Bos taurus
1.8.1.7 0.313
-
 Ni2+ with GSSG as the varied substrate, pH 7.4, 37°C Bos taurus
1.8.1.7 0.32
-
 Zn2+ with GSSG as the varied substrate, pH 7.4, 37°C Bos taurus
1.8.1.7 0.761
-
 Zn2+ with NADPH as the varied substrate, pH 7.4, 37°C Bos taurus
1.8.1.7 0.932
-
 Ni2+ with NADPH as the varied substrate, pH 7.4, 37°C Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.8.1.7 0.08
-
 pH 7.4, 37°C Bos taurus Cd2+
1.8.1.7 0.8
-
 pH 7.4, 37°C Bos taurus Ni2+
1.8.1.7 1
-
 pH 7.4, 37°C Bos taurus Zn2+