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Literature summary extracted from

  • Amin, E.; Saboury, A.; Mansuri-Torshizi, H.; Moosavi-Movahedi, A.
    Potent inhibitory effects of benzyl and p-xylidine-bis dithiocarbamate sodium salts on activities of mushroom tyrosinase (2010), J. Enzyme Inhib. Med. Chem., 25, 272-281.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 4-xylidine-bis(dithiocarbamate) sodium salt Na-SSC-NH-CH2-C6H4-CH2-NH-CSS-Na, mixed-type inhibition for both, catecholase and cresolase activities Agaricus bisporus
1.14.18.1 benzyldithiocarbamate sodium salt C6H5-CH2-NH-CSS-Na, noncompetitive inhibition for both, catecholase and cresolase activities Agaricus bisporus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.18.1 additional information Agaricus bisporus tyrosinase possesses cresolase/monophenolase and/or catecholase/diphenolase activities ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-DOPA + O2
-
 Agaricus bisporus dopaquinone + H2O
-
 ?
1.14.18.1 L-tyrosine + O2
-
 Agaricus bisporus L-DOPA + H2O
-
 ?
1.14.18.1 additional information tyrosinase possesses cresolase/monophenolase and/or catecholase/diphenolase activities Agaricus bisporus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 monophenol monooxygenase
-
 Agaricus bisporus
1.14.18.1 polyphenol oxidase
-
 Agaricus bisporus
1.14.18.1 tyrosinase
-
 Agaricus bisporus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.18.1 0.00029
-
 4-xylidine-bis(dithiocarbamate) sodium salt catecholase activity inhibition, in 50 mM phosphate buffer (pH 6.8), at 27°C Agaricus bisporus
1.14.18.1 0.00064
-
 4-xylidine-bis(dithiocarbamate) sodium salt cresolase activity inhibition, in 50 mM phosphate buffer (pH 6.8), at 27°C Agaricus bisporus
1.14.18.1 0.00095
-
 4-xylidine-bis(dithiocarbamate) sodium salt cresolase activity inhibition, in 50 mM phosphate buffer (pH 6.8), at 37°C Agaricus bisporus
1.14.18.1 0.00105
-
 4-xylidine-bis(dithiocarbamate) sodium salt catecholase activity inhibition, in 50 mM phosphate buffer (pH 6.8), at 37°C Agaricus bisporus
1.14.18.1 0.0057
-
 benzyldithiocarbamate sodium salt catecholase activity inhibition, in 50 mM phosphate buffer (pH 6.8), at 37°C Agaricus bisporus
1.14.18.1 0.0059
-
 benzyldithiocarbamate sodium salt cresolase activity inhibition, in 50 mM phosphate buffer (pH 6.8), at 37°C Agaricus bisporus
1.14.18.1 0.0094
-
 benzyldithiocarbamate sodium salt catecholase activity inhibition, in 50 mM phosphate buffer (pH 6.8), at 27°C Agaricus bisporus
1.14.18.1 0.0141
-
 benzyldithiocarbamate sodium salt cresolase activity inhibition, in 50 mM phosphate buffer (pH 6.8), at 27°C Agaricus bisporus