Literature summary extracted from

Busch, A.; Lacal, J.; Silva-Jimenez, H.; Krell, T.; Ramos, J.L.
Catabolite repression of the TodS/TodT two-component system and effector-dependent transphosphorylation of TodT as the basis for toluene dioxygenase catabolic pathway control (2010), J. Bacteriol., 192, 4246-4250.

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.12.11	Pseudomonas putida	-	-	-

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.12.11	Tod	-	Pseudomonas putida

Expression

EC Number	Organism	Comment	Expression
1.14.12.11	Pseudomonas putida	the todST operon is transcribed from a main promoter and that the +1 initiation point is located 31 nucleotides upstream from the A of the first ATG codon and is preceded by a -10/-35 canonical promoter. Expression from PtodS is under catabolite control, and in cells growing with glucose, the level of expression from this promoter is reduced, which in turn translates to low levels of the TodS/TodT regulators and results in a decrease of transcription from the PtodX promoter. The main underlying regulatory mechanisms of the tod structural genes are at the levels of catabolite repression control from PtodS and transcription activation, mediated by the TodT response regulator through a regulatory cascade in which the effector enhances autophosphorylation of TodS by ATP, with subsequent transphosphorylation of TodT	down

General Information

EC Number	General Information	Comment	Organism
1.14.12.11	metabolism	the TodS/TodT two-component system of Pseudomonas putida regulates the expression of the toluene dioxygenase, tod, operon for the metabolism of toluene, benzene, and ethylbenzene, overview. The TodT protein is the cognate response regulator that activates transcription of the toluene dioxygenase, TOD, pathway genes at the PtodX promoter, expression from PtodS is under catabolite control, detailed overview	Pseudomonas putida

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Release 2023.1 (January 2023)