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Literature summary extracted from

  • van der Westhuyzen, R.; Strauss, E.
    Michael acceptor-containing coenzyme A analogues as inhibitors of the atypical coenzyme A disulfide reductase from Staphylococcus aureus (2010), J. Am. Chem. Soc., 132, 12853-12855.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.14 (E)-2-(methylsulfonyl)ethenyl-CoA competitive inhibition Staphylococcus aureus
1.8.1.14 (E)-2-(phenylsulfonyl)ethenyl-CoA competitive inhibition Staphylococcus aureus
1.8.1.14 ethyl (2E)-prop-2-en-3-CoA-oate competitive inhibition Staphylococcus aureus
1.8.1.14 t-butyl (2E)-prop-2-en-3-CoA-oate competitive inhibition Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.14 Staphylococcus aureus
-
-
-

Synonyms

EC Number Synonyms Comment Organism
1.8.1.14 CoADR
-
 Staphylococcus aureus
1.8.1.14 coenzyme A disulfide reductase
-
 Staphylococcus aureus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.14 NADPH
-
 Staphylococcus aureus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.8.1.14 0.00004
-
 (E)-2-(phenylsulfonyl)ethenyl-CoA temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 Staphylococcus aureus
1.8.1.14 0.0003
-
 (E)-2-(methylsulfonyl)ethenyl-CoA temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 Staphylococcus aureus
1.8.1.14 0.00066
-
 ethyl (2E)-prop-2-en-3-CoA-oate temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 Staphylococcus aureus
1.8.1.14 0.00516
-
 t-butyl (2E)-prop-2-en-3-CoA-oate temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 Staphylococcus aureus