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Literature summary extracted from

  • Kao, T.T.; Tu, H.C.; Chang, W.N.; Chen, B.H.; Shi, Y.Y.; Chang, T.C.; Fu, T.F.
    Grape seed extract inhibits the growth and pathogenicity of Staphylococcus aureus by interfering with dihydrofolate reductase activity and folate-mediated one-carbon metabolism (2010), Int. J. Food Microbiol., 141, 17-27.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.5.1.3 medicine significantly reduced inflammatory responses and mortality are observed in zebrafish infected with Staphylococcus aureus pre-incubated with grape seed extract. Grape seed extract might serve as an effective natural alternative for the control of food poisoning caused by Staphylococcus aureus with proper safety measure Staphylococcus aureus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.5.1.3 expressed in Escherichia coli as a His-tagged fusion protein Staphylococcus aureus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.3 grape seed extract grape seed extract inhibits the dihydrofolate reductase activity and growth of Staphylococcus aureus. The grape seed extract-induced growth inhibition is reversed by adding, tetrahydrofolate, 5,10-methylenetetrahydrofolate or methionine to the medium Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.3 Staphylococcus aureus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.3 dihydrofolate + NADPH + H+
-
Staphylococcus aureus tetrahydrofolate + NADP+
-
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Synonyms

EC Number Synonyms Comment Organism
1.5.1.3 DHFR
-
Staphylococcus aureus
1.5.1.3 dihydrofolate reductase
-
Staphylococcus aureus