Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Zhao, Y.; Seefeldt, T.; Chen, W.; Carlson, L.; Stoebner, A.; Hanson, S.; Foll, R.; Matthees, D.P.; Palakurthi, S.; Guan, X.
    Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation (2009), Free Radic. Biol. Med., 47, 176-183.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 2-acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)phenylthiocarbamoylsulfanyl]propionic acid irreversible glutathione reductase inhibitor Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.7 A-431 cell
-
Homo sapiens
-
1.8.1.7 MCF-7 cell
-
Homo sapiens
-
1.8.1.7 NCI-H226 cell
-
Homo sapiens
-
1.8.1.7 OVCAR-3 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 glutathione disulfide + NADPH + H+
-
Homo sapiens glutathione + NADP+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.7 glutathione reductase
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.7 FAD
-
Homo sapiens
1.8.1.7 NADPH
-
Homo sapiens

General Information

EC Number General Information Comment Organism
1.8.1.7 malfunction glutathione reductase inhibition significantly enhances cancer sensitivity to X-ray irradiation through glutathione disulfide increase Homo sapiens