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Literature summary extracted from
- An unusual plant triterpene synthase with predominant alpha-amyrin-producing activity identified by characterizing oxidosqualene cyclases from Malus × domestica (2011), FEBS J., 278, 2485-2499.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 5.4.99.39 | expressed in Nicotiana benthamiana leaves and in Pichia methanolica | Malus domestica |
| 5.4.99.40 | expressed by transient expression in Nicotiana benthamiana leaves and by expression in the yeast Pichia methanolica | Malus domestica |
| 5.4.99.40 | expressed in Nicotiana benthamiana leaves and in Pichia methanolica | Malus domestica |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.4.99.40 | (3S)-2,3-epoxy-2,3-dihydrosqualene | Malus domestica | the product alpha-amyrin is a precursor of ursolic acid | alpha-amyrin | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.4.99.39 | Malus domestica | C7SCX1 | - |
- |
| 5.4.99.40 | Malus domestica | - |
cultivar Royal Gala | - |
| 5.4.99.40 | Malus domestica | C7SCX0 | Royal Gala | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.4.99.39 | fruit peel | - |
Malus domestica | - |
| 5.4.99.40 | exocarp | - |
Malus domestica | - |
| 5.4.99.40 | fruit | exocarp | Malus domestica | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.4.99.40 | (3S)-2,3-epoxy-2,3-dihydrosqualene | the product alpha-amyrin is a precursor of ursolic acid | Malus domestica | alpha-amyrin | - |
? | |
| 5.4.99.40 | (3S)-2,3-epoxy-2,3-dihydrosqualene | the mixed amyrin synthase produces both alpha- and beta-amyrin in a ration of 5:1 | Malus domestica | alpha-amyrin | - |
? | |
| 5.4.99.40 | (S)-2,3-oxidosqualene | - |
Malus domestica | alpha-amyrin + beta-amyrin | OSC1 produces a 5:1 ratio of alpha-amyrin to beta-amyrin | ? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.4.99.39 | OSC2 | - |
Malus domestica |
| 5.4.99.40 | alpha-amyrin synthase | - |
Malus domestica |
| 5.4.99.40 | alpha/beta amyrin synthase | - |
Malus domestica |
| 5.4.99.40 | MdOSC1 | - |
Malus domestica |
| 5.4.99.40 | mixed amyrin synthase | - |
Malus domestica |
| 5.4.99.40 | OSC1 | isoform | - |
| 5.4.99.40 | OSC1 | isoform | Malus domestica |
| 5.4.99.40 | OSC3 | isoform | - |
| 5.4.99.40 | OSC3 | isoform | Malus domestica |
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Release 2023.1 (January 2023)
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