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Literature summary extracted from
- Synthesis and biological evaluation of [1,2,4]triazino[4,3-a] benzimidazole acetic acid derivatives as selective aldose reductase inhibitors (2010), Eur. J. Med. Chem., 45, 909-914.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.19 | additional information | synthesis and evaluation of acetic acid derivatives of [1,2,4]triazino[4,3-a]benzimidazole, the compounds do not inhibit aldehyde reductase, overview | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.19 | D-glucuronate + NADPH + H+ | Rattus norvegicus | ALR1 | ? + NADP+ | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.19 | Rattus norvegicus | - |
albino rats | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.19 | D-glucuronate + NADPH + H+ | ALR1 | Rattus norvegicus | ? + NADP+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.19 | ALR1 | - |
Rattus norvegicus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.19 | 37 | - |
assay at, ALR1 | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.19 | 8 | - |
assay at, ALR1 | Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.19 | NADPH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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