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Literature summary extracted from

  • Mattheus, W.; Masschelein, J.; Gao, L.J.; Herdewijn, P.; Landuyt, B.; Volckaert, G.; Lavigne, R.
    The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target (2010), Chem. Biol., 17, 1067-1071.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.44 wild-type and deletion mutant BatG expression in Pseudomonas fluorescens strain BCCM_ID9359, Escherichia coli, and Staphylococcus aureus, confers resistance against kalimantacin/batumin Pseudomonas fluorescens

Protein Variants

EC Number Protein Variants Comment Organism
1.3.1.44 additional information generation of a specific in vivo gene inactivation by in-frame deletion of BatG Pseudomonas fluorescens

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.44 Pseudomonas fluorescens
-
-
-
1.3.1.44 Pseudomonas fluorescens BCCM_ID9359
-
-
-

Synonyms

EC Number Synonyms Comment Organism
1.3.1.44 BatG
-
 Pseudomonas fluorescens
1.3.1.44 More BatG as a trans-2-enoyl-ACP reductase isozyme, an isozyme of FabI, it contains the conserved NADH-binding motif GxxxGxG and catalytic triad YYK Pseudomonas fluorescens
1.3.1.44 trans-2-enoyl-ACP reductase
-
 Pseudomonas fluorescens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.44 NAD+
-
 Pseudomonas fluorescens
1.3.1.44 NADH
-
 Pseudomonas fluorescens
1.3.1.44 NADP+
-
 Pseudomonas fluorescens
1.3.1.44 NADPH
-
 Pseudomonas fluorescens

General Information

EC Number General Information Comment Organism
1.3.1.44 additional information BatG is an isoform of FabI, conferring full resistance to target bacteria against kalimantacin/batumin and/or triclosan Pseudomonas fluorescens
1.3.1.44 physiological function BatG encodes a functional FabI isozyme which confers full resistance to kalimantacin/batumin and complements FabI. BatG is, similarity to trans-2-enoyl-ACP reductases, involved in the formation of a saturated acyl-ACP by an NAD(P)H-dependent reduction of the trans-2-enoyl-ACP double bond, which is essential for the final step of the elongation cycle of fatty acid biosynthesis. BatG knockout does not influence the kalimantacin/batumin, kal/bat, biosynthesis structurally. Kalimantacin/batumin biosynthesis is BatG-independent, despite BatG localization in the operon among kal/bat tailoring enzymes, overview Pseudomonas fluorescens