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Literature summary extracted from

  • Rajic, Z.; Hadjipavlou-Litina, D.; Pontiki, E.; Kralj, M.; Suman, L.; Zorc, B.
    The novel ketoprofen amides--synthesis and biological evaluation as antioxidants, lipoxygenase inhibitors and cytostatic agents (2010), Chem. Biol. Drug Des., 75, 641-652.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.12 2-(3-(hydroxy(phenyl)methyl)phenyl)-N-phenethylpropanamide
-
 Glycine max
1.13.11.12 2-(3-(hydroxy(phenyl)methyl)phenyl)propanoic acid
-
 Glycine max
1.13.11.12 2-(3-benzoylphenyl)-N-(cyclohexylmethyl)propanamide
-
 Glycine max
1.13.11.12 2-(3-benzoylphenyl)-N-cyclohexylpropanamide
-
 Glycine max
1.13.11.12 2-(3-benzoylphenyl)-N-cyclopentylpropanamide
-
 Glycine max
1.13.11.12 2-(3-benzoylphenyl)-N-phenethylpropanamide
-
 Glycine max
1.13.11.12 2-(3-benzylphenyl)-N,N-bis(2-hydroxyethyl)propanamide
-
 Glycine max
1.13.11.12 2-(3-benzylphenyl)-N-(2-hydroxyethyl)propanamide
-
 Glycine max
1.13.11.12 2-(3-benzylphenyl)-N-(3-hydroxypropyl)propanamide
-
 Glycine max
1.13.11.12 2-(3-benzylphenyl)-N-(cyclohexylemethyl)propanamide
-
 Glycine max
1.13.11.12 2-(3-benzylphenyl)-N-cyclohexylpropanamide
-
 Glycine max
1.13.11.12 2-(3-benzylphenyl)-N-cyclopentylpropanamide
-
 Glycine max
1.13.11.12 2-(3-benzylphenyl)-N-ethoxypropanamide
-
 Glycine max
1.13.11.12 2-(3-benzylphenyl)-N-methoxypropanamide 12% and 27.5% inhibition at 0.1 and 0.5 mM, respectively Glycine max
1.13.11.12 2-(3-benzylphenyl)-N-phenethylpropanamide
-
 Glycine max
1.13.11.12 2-(3-benzylphenyl)propanamide
-
 Glycine max
1.13.11.12 2-(3-benzylphenyl)propanoic acid
-
 Glycine max
1.13.11.12 caffeic acid
-
 Glycine max
1.13.11.12 Ketoprofen
-
 Glycine max
1.13.11.12 N-(cyclohexylmethyl)-2-{3-[hydroxy(phenyl)methyl]phenyl}propanamide
-
 Glycine max
1.13.11.12 N-benzhydryl-2-(3-(hydroxy(phenyl)methyl)phenyl)propanamide
-
 Glycine max
1.13.11.12 N-benzhydryl-2-(3-benzoylphenyl)propanamide
-
 Glycine max
1.13.11.12 N-benzhydryl-2-(3-benzylphenyl)propanamide
-
 Glycine max
1.13.11.12 N-benzyl-2-(3-(hydroxy(phenyl)methyl)phenyl)propanamide
-
 Glycine max
1.13.11.12 N-benzyl-2-(3-benzoylphenyl)propanamide
-
 Glycine max
1.13.11.12 N-benzyl-2-(3-benzylphenyl)propanamide
-
 Glycine max
1.13.11.12 N-benzyloxy-2-(3-benzylphenyl)propanamide
-
 Glycine max
1.13.11.12 N-cyclohexyl-2-(3-(hydroxy(phenyl)methyl)phenyl)propanamide
-
 Glycine max
1.13.11.12 N-cyclopentyl-2-(3-(hydroxy(phenyl)methyl)phenyl)propanamide
-
 Glycine max
1.13.11.12 N-hydroxy-2-(3-(hydroxy(phenyl)methyl)phenyl)propanamide
-
 Glycine max

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.12 Glycine max
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.12 linoleate + O2
-
 Glycine max (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.12 LOX
-
 Glycine max

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.13.11.12 0.0205
-
 25°C, pH not specified in the publication Glycine max N-benzhydryl-2-(3-(hydroxy(phenyl)methyl)phenyl)propanamide
1.13.11.12 0.0375
-
 25°C, pH not specified in the publication Glycine max 2-(3-benzylphenyl)-N-cyclohexylpropanamide
1.13.11.12 0.043
-
 25°C, pH not specified in the publication Glycine max 2-(3-benzylphenyl)-N-phenethylpropanamide
1.13.11.12 0.05
-
 25°C, pH not specified in the publication Glycine max N-benzhydryl-2-(3-benzylphenyl)propanamide
1.13.11.12 0.053
-
 25°C, pH not specified in the publication Glycine max 2-(3-benzoylphenyl)-N-(cyclohexylmethyl)propanamide
1.13.11.12 0.0615
-
 25°C, pH not specified in the publication Glycine max 2-(3-benzoylphenyl)-N-cyclopentylpropanamide
1.13.11.12 0.0645
-
 25°C, pH not specified in the publication Glycine max N-benzhydryl-2-(3-benzoylphenyl)propanamide
1.13.11.12 0.065
-
 25°C, pH not specified in the publication Glycine max 2-(3-benzoylphenyl)-N-phenethylpropanamide
1.13.11.12 0.0745
-
 25°C, pH not specified in the publication Glycine max N-benzyl-2-(3-benzylphenyl)propanamide
1.13.11.12 0.08
-
 25°C, pH not specified in the publication Glycine max 2-(3-benzylphenyl)-N-(cyclohexylemethyl)propanamide
1.13.11.12 0.082
-
 25°C, pH not specified in the publication Glycine max 2-(3-benzylphenyl)-N-cyclopentylpropanamide
1.13.11.12 0.0875
-
 25°C, pH not specified in the publication Glycine max N-benzyl-2-(3-benzoylphenyl)propanamide
1.13.11.12 0.1
-
 25°C, pH not specified in the publication Glycine max N-benzyloxy-2-(3-benzylphenyl)propanamide
1.13.11.12 0.12
-
 25°C, pH not specified in the publication Glycine max 2-(3-benzoylphenyl)-N-cyclohexylpropanamide
1.13.11.12 0.12
-
 25°C, pH not specified in the publication Glycine max 2-(3-(hydroxy(phenyl)methyl)phenyl)-N-phenethylpropanamide
1.13.11.12 0.13
-
 25°C, pH not specified in the publication Glycine max Ketoprofen
1.13.11.12 0.13
-
 25°C, pH not specified in the publication Glycine max 2-(3-(hydroxy(phenyl)methyl)phenyl)propanoic acid
1.13.11.12 0.2
-
 25°C, pH not specified in the publication Glycine max N-benzyl-2-(3-(hydroxy(phenyl)methyl)phenyl)propanamide
1.13.11.12 0.2
-
 25°C, pH not specified in the publication Glycine max N-hydroxy-2-(3-(hydroxy(phenyl)methyl)phenyl)propanamide
1.13.11.12 0.23
-
 25°C, pH not specified in the publication Glycine max N-cyclopentyl-2-(3-(hydroxy(phenyl)methyl)phenyl)propanamide
1.13.11.12 0.27
-
 25°C, pH not specified in the publication Glycine max 2-(3-benzylphenyl)-N-(2-hydroxyethyl)propanamide
1.13.11.12 0.28
-
 25°C, pH not specified in the publication Glycine max 2-(3-benzylphenyl)-N-(3-hydroxypropyl)propanamide
1.13.11.12 0.295
-
 25°C, pH not specified in the publication Glycine max N-(cyclohexylmethyl)-2-{3-[hydroxy(phenyl)methyl]phenyl}propanamide
1.13.11.12 0.325
-
 25°C, pH not specified in the publication Glycine max 2-(3-benzylphenyl)propanamide
1.13.11.12 0.385
-
 25°C, pH not specified in the publication Glycine max 2-(3-benzylphenyl)-N-ethoxypropanamide
1.13.11.12 0.4
-
 25°C, pH not specified in the publication Glycine max 2-(3-benzylphenyl)-N,N-bis(2-hydroxyethyl)propanamide
1.13.11.12 0.415
-
 25°C, pH not specified in the publication Glycine max 2-(3-benzylphenyl)propanoic acid
1.13.11.12 0.425
-
 25°C, pH not specified in the publication Glycine max N-cyclohexyl-2-(3-(hydroxy(phenyl)methyl)phenyl)propanamide
1.13.11.12 0.6
-
 25°C, pH not specified in the publication Glycine max caffeic acid