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Literature summary extracted from

  • Gangjee, A.; Jain, H.D.; Phan, J.; Guo, X.; Queener, S.F.; Kisliuk, R.L.
    2,4-Diamino-5-methyl-6-substituted arylthio-furo[2,3-d]pyrimidines as novel classical and nonclassical antifolates as potential dual thymidylate synthase and dihydrofolate reductase inhibitors (2010), Bioorg. Med. Chem., 18, 953-961.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.3 2,4-diamino-5-methyl-6-(1-naphthylthio)furo[2,3-d]pyrimidine
-
 Pneumocystis carinii
1.5.1.3 2,4-diamino-5-methyl-6-(1-naphthylthio)furo[2,3-d]pyrimidine
-
 Rattus norvegicus
1.5.1.3 2,4-diamino-5-methyl-6-(1-naphthylthio)furo[2,3-d]pyrimidine
-
 Toxoplasma gondii
1.5.1.3 2,4-diamino-5-methyl-6-(2',3',5',6'-tetrafluoro-4'-trifluoromethylphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Mycobacterium avium
1.5.1.3 2,4-diamino-5-methyl-6-(2',3',5',6'-tetrafluoro-4'-trifluoromethylphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Pneumocystis carinii
1.5.1.3 2,4-diamino-5-methyl-6-(2',3',5',6'-tetrafluoro-4'-trifluoromethylphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Rattus norvegicus
1.5.1.3 2,4-diamino-5-methyl-6-(2',3',5',6'-tetrafluoro-4'-trifluoromethylphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Toxoplasma gondii
1.5.1.3 2,4-diamino-5-methyl-6-(2',5'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Mycobacterium avium
1.5.1.3 2,4-diamino-5-methyl-6-(2',5'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Pneumocystis carinii
1.5.1.3 2,4-diamino-5-methyl-6-(2',5'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Rattus norvegicus
1.5.1.3 2,4-diamino-5-methyl-6-(2',5'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Toxoplasma gondii
1.5.1.3 2,4-diamino-5-methyl-6-(2',6'-dichlorophenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Mycobacterium avium
1.5.1.3 2,4-diamino-5-methyl-6-(2',6'-dichlorophenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Pneumocystis carinii
1.5.1.3 2,4-diamino-5-methyl-6-(2',6'-dichlorophenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Rattus norvegicus
1.5.1.3 2,4-diamino-5-methyl-6-(2',6'-dichlorophenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Toxoplasma gondii
1.5.1.3 2,4-diamino-5-methyl-6-(2',6'-dimethylphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Mycobacterium avium
1.5.1.3 2,4-diamino-5-methyl-6-(2',6'-dimethylphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Pneumocystis carinii
1.5.1.3 2,4-diamino-5-methyl-6-(2',6'-dimethylphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Rattus norvegicus
1.5.1.3 2,4-diamino-5-methyl-6-(2',6'-dimethylphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Toxoplasma gondii
1.5.1.3 2,4-diamino-5-methyl-6-(2'-isopropyl-6'-methylphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Mycobacterium avium
1.5.1.3 2,4-diamino-5-methyl-6-(2'-isopropyl-6'-methylphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Pneumocystis carinii
1.5.1.3 2,4-diamino-5-methyl-6-(2'-isopropyl-6'-methylphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Rattus norvegicus
1.5.1.3 2,4-diamino-5-methyl-6-(2'-isopropyl-6'-methylphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Toxoplasma gondii
1.5.1.3 2,4-diamino-5-methyl-6-(2'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Mycobacterium avium
1.5.1.3 2,4-diamino-5-methyl-6-(2'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Pneumocystis carinii
1.5.1.3 2,4-diamino-5-methyl-6-(2'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Rattus norvegicus
1.5.1.3 2,4-diamino-5-methyl-6-(2'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Toxoplasma gondii
1.5.1.3 2,4-diamino-5-methyl-6-(2-naphthylthio)furo[2,3-d]pyrimidine
-
 Pneumocystis carinii
1.5.1.3 2,4-diamino-5-methyl-6-(2-naphthylthio)furo[2,3-d]pyrimidine
-
 Rattus norvegicus
1.5.1.3 2,4-diamino-5-methyl-6-(2-naphthylthio)furo[2,3-d]pyrimidine
-
 Toxoplasma gondii
1.5.1.3 2,4-diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Mycobacterium avium
1.5.1.3 2,4-diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Pneumocystis carinii
1.5.1.3 2,4-diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Rattus norvegicus
1.5.1.3 2,4-diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Toxoplasma gondii
1.5.1.3 2,4-diamino-5-methyl-6-(3'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Mycobacterium avium
1.5.1.3 2,4-diamino-5-methyl-6-(3'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Pneumocystis carinii
1.5.1.3 2,4-diamino-5-methyl-6-(3'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Rattus norvegicus
1.5.1.3 2,4-diamino-5-methyl-6-(3'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Toxoplasma gondii
1.5.1.3 2,4-diamino-5-methyl-6-(4'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Mycobacterium avium
1.5.1.3 2,4-diamino-5-methyl-6-(4'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Pneumocystis carinii
1.5.1.3 2,4-diamino-5-methyl-6-(4'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Rattus norvegicus
1.5.1.3 2,4-diamino-5-methyl-6-(4'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
-
 Toxoplasma gondii
1.5.1.3 N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)-thio]-benzoyl]-L-glutamic acid
-
 Mycobacterium avium
1.5.1.3 N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)-thio]-benzoyl]-L-glutamic acid
-
 Pneumocystis carinii
1.5.1.3 N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)-thio]-benzoyl]-L-glutamic acid
-
 Rattus norvegicus
1.5.1.3 N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)-thio]-benzoyl]-L-glutamic acid
-
 Toxoplasma gondii
2.1.1.45 methotrexate
-
 Escherichia coli
2.1.1.45 methotrexate
-
 Homo sapiens
2.1.1.45 methotrexate
-
 Toxoplasma gondii
2.1.1.45 N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)thio]-benzoyl]-L-glutamic acid
-
 Escherichia coli
2.1.1.45 N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)thio]-benzoyl]-L-glutamic acid
-
 Homo sapiens
2.1.1.45 N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)thio]-benzoyl]-L-glutamic acid
-
 Toxoplasma gondii
2.1.1.45 pemetrexed
-
 Escherichia coli
2.1.1.45 pemetrexed
-
 Homo sapiens
2.1.1.45 pemetrexed
-
 Toxoplasma gondii
2.1.1.45 raltitrexed
-
 Escherichia coli
2.1.1.45 raltitrexed
-
 Homo sapiens
2.1.1.45 raltitrexed
-
 Toxoplasma gondii
2.1.1.45 trimethoprim
-
 Escherichia coli
2.1.1.45 trimethoprim
-
 Homo sapiens
2.1.1.45 trimethoprim
-
 Toxoplasma gondii
2.1.1.45 trimetrexate
-
 Escherichia coli
2.1.1.45 trimetrexate
-
 Homo sapiens
2.1.1.45 trimetrexate
-
 Toxoplasma gondii

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.3 Mycobacterium avium
-
-
-
1.5.1.3 Pneumocystis carinii
-
-
-
1.5.1.3 Rattus norvegicus
-
-
-
1.5.1.3 Toxoplasma gondii
-
-
-
2.1.1.45 Escherichia coli
-
-
-
2.1.1.45 Homo sapiens
-
-
-
2.1.1.45 Toxoplasma gondii
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.3 liver
-
 Rattus norvegicus
-
1.5.1.3 liver
-
 Mycobacterium avium
-
1.5.1.3 liver
-
 Toxoplasma gondii
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.3 dihydrofolate + NADPH + H+
-
 Rattus norvegicus tetrahydrofolate + NADP+
-
 ?
1.5.1.3 dihydrofolate + NADPH + H+
-
 Mycobacterium avium tetrahydrofolate + NADP+
-
 ?
1.5.1.3 dihydrofolate + NADPH + H+
-
 Pneumocystis carinii tetrahydrofolate + NADP+
-
 ?
1.5.1.3 dihydrofolate + NADPH + H+
-
 Toxoplasma gondii tetrahydrofolate + NADP+
-
 ?
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Escherichia coli dihydrofolate + dTMP
-
 ?
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Homo sapiens dihydrofolate + dTMP
-
 ?
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Toxoplasma gondii dihydrofolate + dTMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.3 DHFR
-
 Rattus norvegicus
1.5.1.3 DHFR
-
 Mycobacterium avium
1.5.1.3 DHFR
-
 Pneumocystis carinii
1.5.1.3 DHFR
-
 Toxoplasma gondii
1.5.1.3 dihydrofolate reductase
-
 Rattus norvegicus
1.5.1.3 dihydrofolate reductase
-
 Mycobacterium avium
1.5.1.3 dihydrofolate reductase
-
 Pneumocystis carinii
1.5.1.3 dihydrofolate reductase
-
 Toxoplasma gondii

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.5.1.3 37
-
 assay at Rattus norvegicus
1.5.1.3 37
-
 assay at Mycobacterium avium
1.5.1.3 37
-
 assay at Pneumocystis carinii
1.5.1.3 37
-
 assay at Toxoplasma gondii

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.3 NADPH
-
 Rattus norvegicus
1.5.1.3 NADPH
-
 Mycobacterium avium
1.5.1.3 NADPH
-
 Pneumocystis carinii
1.5.1.3 NADPH
-
 Toxoplasma gondii

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.5.1.3 0.00000973
-
 37°C, pH not specified in the publication Mycobacterium avium N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)-thio]-benzoyl]-L-glutamic acid
1.5.1.3 0.000078
-
 37°C, pH not specified in the publication Pneumocystis carinii N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)-thio]-benzoyl]-L-glutamic acid
1.5.1.3 0.0086
-
 37°C, pH not specified in the publication Pneumocystis carinii 2,4-diamino-5-methyl-6-(1-naphthylthio)furo[2,3-d]pyrimidine
1.5.1.3 0.012
-
 37°C, pH not specified in the publication Toxoplasma gondii N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)-thio]-benzoyl]-L-glutamic acid
1.5.1.3 0.012
-
 37°C, pH not specified in the publication Pneumocystis carinii 2,4-diamino-5-methyl-6-(2-naphthylthio)furo[2,3-d]pyrimidine
1.5.1.3 0.012
-
 37°C, pH not specified in the publication, value above Rattus norvegicus 2,4-diamino-5-methyl-6-(2-naphthylthio)furo[2,3-d]pyrimidine
1.5.1.3 0.012
-
 37°C, pH not specified in the publication, value above Toxoplasma gondii 2,4-diamino-5-methyl-6-(2-naphthylthio)furo[2,3-d]pyrimidine
1.5.1.3 0.0144
-
 37°C, pH not specified in the publication Rattus norvegicus 2,4-diamino-5-methyl-6-(2',6'-dichlorophenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.016
-
 37°C, pH not specified in the publication Mycobacterium avium 2,4-diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.016
-
 37°C, pH not specified in the publication Toxoplasma gondii 2,4-diamino-5-methyl-6-(2'-isopropyl-6'-methylphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.019
-
 37°C, pH not specified in the publication Toxoplasma gondii 2,4-diamino-5-methyl-6-(2',6'-dimethylphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.02
-
 37°C, pH not specified in the publication Pneumocystis carinii 2,4-diamino-5-methyl-6-(2',6'-dimethylphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.02
-
 37°C, pH not specified in the publication Pneumocystis carinii 2,4-diamino-5-methyl-6-(2'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.0205
-
 37°C, pH not specified in the publication Rattus norvegicus N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)-thio]-benzoyl]-L-glutamic acid
1.5.1.3 0.023
-
 37°C, pH not specified in the publication Mycobacterium avium 2,4-diamino-5-methyl-6-(2'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.023
-
 37°C, pH not specified in the publication Mycobacterium avium 2,4-diamino-5-methyl-6-(2'-isopropyl-6'-methylphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.024
-
 37°C, pH not specified in the publication Pneumocystis carinii 2,4-diamino-5-methyl-6-(2',5'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.024
-
 37°C, pH not specified in the publication Rattus norvegicus 2,4-diamino-5-methyl-6-(2'-isopropyl-6'-methylphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.025
-
 37°C, pH not specified in the publication Toxoplasma gondii 2,4-diamino-5-methyl-6-(2',6'-dichlorophenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.025
-
 37°C, pH not specified in the publication Mycobacterium avium 2,4-diamino-5-methyl-6-(4'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.025
-
 37°C, pH not specified in the publication Pneumocystis carinii 2,4-diamino-5-methyl-6-(3'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.028
-
 37°C, pH not specified in the publication Mycobacterium avium 2,4-diamino-5-methyl-6-(3'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.031
-
 37°C, pH not specified in the publication Mycobacterium avium 2,4-diamino-5-methyl-6-(2',3',5',6'-tetrafluoro-4'-trifluoromethylphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.031
-
 37°C, pH not specified in the publication Pneumocystis carinii 2,4-diamino-5-methyl-6-(2',3',5',6'-tetrafluoro-4'-trifluoromethylphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.0347
-
 37°C, pH not specified in the publication Pneumocystis carinii 2,4-diamino-5-methyl-6-(4'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.036
-
 37°C, pH not specified in the publication Pneumocystis carinii 2,4-diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.036
-
 37°C, pH not specified in the publication Pneumocystis carinii 2,4-diamino-5-methyl-6-(2'-isopropyl-6'-methylphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.038
-
 37°C, pH not specified in the publication Toxoplasma gondii 2,4-diamino-5-methyl-6-(2',5'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.039
-
 37°C, pH not specified in the publication Rattus norvegicus 2,4-diamino-5-methyl-6-(2',3',5',6'-tetrafluoro-4'-trifluoromethylphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.042
-
 37°C, pH not specified in the publication Rattus norvegicus 2,4-diamino-5-methyl-6-(2',5'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.044
-
 37°C, pH not specified in the publication Toxoplasma gondii 2,4-diamino-5-methyl-6-(2'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.045
-
 37°C, pH not specified in the publication Toxoplasma gondii 2,4-diamino-5-methyl-6-(3'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.051
-
 37°C, pH not specified in the publication Rattus norvegicus 2,4-diamino-5-methyl-6-(3'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.051
-
 37°C, pH not specified in the publication Toxoplasma gondii 2,4-diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.055
-
 37°C, pH not specified in the publication Rattus norvegicus 2,4-diamino-5-methyl-6-(2'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.056
-
 37°C, pH not specified in the publication Mycobacterium avium 2,4-diamino-5-methyl-6-(2',6'-dichlorophenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.06
-
 37°C, pH not specified in the publication Pneumocystis carinii 2,4-diamino-5-methyl-6-(2',6'-dichlorophenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.061
-
 37°C, pH not specified in the publication Mycobacterium avium 2,4-diamino-5-methyl-6-(2',5'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.061
-
 37°C, pH not specified in the publication Rattus norvegicus 2,4-diamino-5-methyl-6-(4'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.066
-
 37°C, pH not specified in the publication Rattus norvegicus 2,4-diamino-5-methyl-6-(3',4'-dimethoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.069
-
 37°C, pH not specified in the publication Toxoplasma gondii 2,4-diamino-5-methyl-6-(4'-methoxyphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.081
-
 37°C, pH not specified in the publication Toxoplasma gondii 2,4-diamino-5-methyl-6-(2',3',5',6'-tetrafluoro-4'-trifluoromethylphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.083
-
 37°C, pH not specified in the publication, value above Rattus norvegicus 2,4-diamino-5-methyl-6-(1-naphthylthio)furo[2,3-d]pyrimidine
1.5.1.3 0.083
-
 37°C, pH not specified in the publication, value above Toxoplasma gondii 2,4-diamino-5-methyl-6-(1-naphthylthio)furo[2,3-d]pyrimidine
1.5.1.3 0.196
-
 37°C, pH not specified in the publication Rattus norvegicus 2,4-diamino-5-methyl-6-(2',6'-dimethylphenylsulfanyl)-furo[2,3-d]pyrimidine
1.5.1.3 0.196
-
 37°C, pH not specified in the publication Mycobacterium avium 2,4-diamino-5-methyl-6-(2',6'-dimethylphenylsulfanyl)-furo[2,3-d]pyrimidine
2.1.1.45 0.00038
-
 at 30°C and pH 7.4 Homo sapiens raltitrexed
2.1.1.45 0.0009
-
 at 30°C and pH 7.4 Toxoplasma gondii raltitrexed
2.1.1.45 0.0028
-
 at 30°C and pH 7.4 Toxoplasma gondii pemetrexed
2.1.1.45 0.0054
-
 at 30°C and pH 7.4 Homo sapiens N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)thio]-benzoyl]-L-glutamic acid
2.1.1.45 0.0057
-
 at 30°C and pH 7.4 Escherichia coli raltitrexed
2.1.1.45 0.0095
-
 at 30°C and pH 7.4 Homo sapiens pemetrexed
2.1.1.45 0.018
-
 at 30°C and pH 7.4 Toxoplasma gondii methotrexate
2.1.1.45 0.027
-
 at 30°C and pH 7.4 Toxoplasma gondii N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)thio]-benzoyl]-L-glutamic acid
2.1.1.45 0.029
-
 at 30°C and pH 7.4 Homo sapiens methotrexate
2.1.1.45 0.076
-
 at 30°C and pH 7.4 Escherichia coli pemetrexed
2.1.1.45 0.09
-
 at 30°C and pH 7.4 Escherichia coli methotrexate
2.1.1.45 0.23
-
 at 30°C and pH 7.4 Escherichia coli N-[4-[(2,4-diamino-5-methyl-furo[2,3-d]pyrimidin-6-yl)thio]-benzoyl]-L-glutamic acid