Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Goekhan-Kelekci, N.; Simsek, O.O.; Ercan, A.; Yelekci, K.; Sahin, Z.S.; I?ik, S.; Ucar, G.; Bilgin, A.A.
    Synthesis and molecular modeling of some novel hexahydroindazole derivatives as potent monoamine oxidase inhibitors (2009), Bioorg. Med. Chem., 17, 6761-6772.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 3-(2-furyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
 Rattus norvegicus
1.4.3.4 3-(2-furyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
 Rattus norvegicus
1.4.3.4 3-(2-furyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
 Rattus norvegicus
1.4.3.4 3-(2-furyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
 Rattus norvegicus
1.4.3.4 3-(2-furyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
-
 Rattus norvegicus
1.4.3.4 3-(2-thienyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
 Rattus norvegicus
1.4.3.4 3-(2-thienyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
 Rattus norvegicus
1.4.3.4 3-(2-thienyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
 Rattus norvegicus
1.4.3.4 3-(2-thienyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
-
 Rattus norvegicus
1.4.3.4 cis-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
 Rattus norvegicus
1.4.3.4 moclobemide
-
 Rattus norvegicus
1.4.3.4 additional information synthesis and molecular modeling of some hexahydroindazole derivatives as potent monoamine oxidase inhibitors, overview Rattus norvegicus
1.4.3.4 selegiline
-
 Rattus norvegicus
1.4.3.4 trans-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.4 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 p-tyramine + H2O + O2
-
 Rattus norvegicus (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO-A
-
 Rattus norvegicus
1.4.3.4 MAO-B
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.4.3.4 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.4 7.6
-
 assay at Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.4.3.4 0.00027
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus 3-(2-thienyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
1.4.3.4 0.00042
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus 3-(2-thienyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
1.4.3.4 0.00053
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus 3-(2-furyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
1.4.3.4 0.0011
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus 3-(2-thienyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
1.4.3.4 0.00127
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus 3-(2-furyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
1.4.3.4 0.00136
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus 3-(2-furyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
1.4.3.4 0.0017
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus 3-(2-thienyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
1.4.3.4 0.002
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus 3-(2-thienyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
1.4.3.4 0.0021
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus 3-(2-thienyl)-2-thiocarbamoyl-2,3,4,5,6,7-hexahydro-1H-indazol
1.4.3.4 0.0025
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus 3-(2-thienyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
1.4.3.4 0.0026
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus 3-(2-thienyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
1.4.3.4 0.00273
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus 3-(2-furyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
1.4.3.4 0.0028
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus 3-(2-furyl)-2-(N-ethylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
1.4.3.4 0.0029
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus 3-(2-furyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
1.4.3.4 0.00318
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus 3-(2-furyl)-2-(N-methylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
1.4.3.4 0.00358
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus 3-(2-furyl)-2-(N-allylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
1.4.3.4 0.0088
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus 3-(2-furyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
1.4.3.4 0.0201
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus trans-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
1.4.3.4 0.0312
-
 pH 7.6, 37°C, MAO-A Rattus norvegicus cis-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
1.4.3.4 0.0695
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus trans-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
1.4.3.4 0.0707
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus 3-(2-furyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol
1.4.3.4 0.0931
-
 pH 7.6, 37°C, MAO-B Rattus norvegicus cis-3-(2-thienyl)-2-(N-phenylthiocarbamoyl)-3,3a,4,5,6,7-hexahydro-2H-indazol