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Literature summary extracted from

  • Papaioannou, E.; Wahjudi, M.; Nadal-Jimenez, P.; Koch, G.; Setroikromo, R.; Quax, W.J.
    Quorum-quenching acylase reduces the virulence of Pseudomonas aeruginosa in a Caenorhabditis elegans infection model (2009), Antimicrob. Agents Chemother., 53, 4891-4897.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.5.1.97 additional information the strain PAO1-DELTApvd is shown to be more virulent than the wild-type strain, confirming the role of PvdQ as a virulence-reducing agent Pseudomonas aeruginosa PAO1

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.97 Pseudomonas aeruginosa PAO1
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 the virulence of Pseudomonas aeruginosa PAO1 is analyzed in a Caenorhabditis elegans infection model
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Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.97 a two-step purification protocol, anion exchange chromatography and hydrophobic interaction chromatography Pseudomonas aeruginosa PAO1

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.97 additional information in the Caenorhabditis elegans infection model it is observed that larval stage 1 to 3 benefit much more from the protection by PvdQ than larval stage 4 worms Pseudomonas aeruginosa PAO1
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.97 N-3-oxododecanoyl-L-homoserine lactone + H2O
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 Pseudomonas aeruginosa PAO1 L-homoserine lactone + 3-oxododecanoic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.97 acyl-homoserine lactone acylase
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 Pseudomonas aeruginosa PAO1
3.5.1.97 AHL acylase
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 Pseudomonas aeruginosa PAO1
3.5.1.97 PvdQ
-
 Pseudomonas aeruginosa PAO1

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.1.97 37
-
 assay at Pseudomonas aeruginosa PAO1

General Information

EC Number General Information Comment Organism
3.5.1.97 physiological function PvdQ functions as a quorum quencher in vitro. Purified PvdQ is added to Caenorhabditis elegans worms infected with wild-type PAO1 and this results in reduced pathogenicity and increases the life span of the nematodes. PvdQ might be a strong candidate for antibacterial therapy against Pseudomonas infections Pseudomonas aeruginosa PAO1