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Literature summary extracted from

  • Saja, S.; Buff, H.; Smith, A.C.; Williams, T.S.; Korey, C.A.
    Identifying cellular pathways modulated by Drosophila palmitoyl-protein thioesterase 1 function (2010), Neurobiol. Dis., 40, 135-145.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.2.22 additional information Drosophila C-terminal Src kinase is an enhancer of the Ppt1 phenotype. Mutations in the fear of intimacy gene are also identified as enhancers. Mutations in zipper or mutations at the Drosophila IGF-II mRNA-binding protein locus enhance the degenerative phenotype. The tsg alleles tsg2 and tsg4 both enhance the rough eye phenotype produced by Ppt1 expression Drosophila sp. (in: flies)

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.2.22 construction of a UAS:GFP-Ppt1 transgenic fly line. The pUAST:GFP-Ppt1 vector overexpressed using Act5C-Gal4 Drosophila sp. (in: flies)
3.1.2.22 overexpressed in Drosophila melanogaster Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
3.1.2.22 A179T loss-of-function allele Drosophila melanogaster
3.1.2.22 A179T loss-of-function allele, although endocytosis and endo-lysosomal trafficking does occur in Ppt1 mutant garland cells, there is a reduced level of uptake and a decreased rate of trafficking to the lysosomes Drosophila sp. (in: flies)
3.1.2.22 S77F loss-of-function allele Drosophila melanogaster
3.1.2.22 S77F loss-of-function allele, although endocytosis and endo-lysosomal trafficking does occur in Ppt1 mutant garland cells, there is a reduced level of uptake and a decreased rate of trafficking to the lysosomes Drosophila sp. (in: flies)

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.2.22 additional information dSmt3 mutations are the lone suppressor modifiers Drosophila sp. (in: flies)

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.22 Drosophila melanogaster
-
-
-
3.1.2.22 Drosophila sp. (in: flies)
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.22 eye
-
Drosophila sp. (in: flies)
-
3.1.2.22 larva
-
Drosophila sp. (in: flies)
-
3.1.2.22 additional information Garland cell Drosophila sp. (in: flies)
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.22 4-methylumbelliferyl 6-S-palmitoyl-6-thio-beta-D-glucoside + H2O
-
Drosophila sp. (in: flies) 4-methylumbelliferyl 6-thio-beta-D-glucoside + palmitate
-
?
3.1.2.22 4-methylumbelliferyl 6-S-palmitoyl-6-thio-beta-D-glucoside + H2O 4MU-6S-palm-beta-Glc Drosophila melanogaster 4-methylumbelliferyl 6-thio-beta-D-glucoside + palmitate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.2.22 palmitoyl-protein thioesterase 1
-
Drosophila melanogaster
3.1.2.22 palmitoyl-protein thioesterase 1
-
Drosophila sp. (in: flies)
3.1.2.22 PPT1
-
Drosophila sp. (in: flies)

General Information

EC Number General Information Comment Organism
3.1.2.22 malfunction Garland cells from Ppt1 loss-of-function mutants have defects in endocytic trafficking Drosophila sp. (in: flies)
3.1.2.22 physiological function Ppt1 plays a role in modulating the early stages of vesicle formation. There may be a connection between Ppt1 and bone morphogenetic protein signaling at the cellular level. Expression of wild-type Ppt1 in the adult visual system using GMR-Gal4 alters the external and internal organization of the adult retina. When co-expressed UAS-dynamin with Ppt1 there is a significant enhancement of the rough eye phenotype Drosophila sp. (in: flies)