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Literature summary extracted from
- Factor XI deficiency in animal models (2009), J. Thromb. Haemost., 7 Suppl 1, 79-83.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.27 | activated factor XII | activates its substrate FXI | Homo sapiens | |
| 3.4.21.27 | Factor XII | FXI is activated by factor XII during ischemia reperfusion injury and within the growing thrombus according to the classical intrinsic pathway cascade | Mus musculus | |
| 3.4.21.27 | thrombin | - |
Mus musculus | |
| 3.4.21.27 | thrombin | thrombin generated early in coagulation by the tissue factor pathway activates FXI creating a positive feedback loop that sustains coagulation following inactivation of the factor VIIa/tissue factor complex by tissue factor pathway inhibitor | Homo sapiens |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.21.27 | medicine | therapeutically targeting FXI may offer a strategy for preventing or treating arterial thrombosis that is not associated with the high rate of hemorrhage that accompanies many currently used anticoagulants. Pharmacological FXI inhibitors may be beneficial in septic disease | Mus musculus |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.27 | 80000 | - |
2 * 80000 | Mus musculus |
| 3.4.21.27 | 80000 | - |
2 * 80000 | Homo sapiens |
| 3.4.21.27 | 160000 | - |
- |
Mus musculus |
| 3.4.21.27 | 160000 | - |
- |
Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.27 | Canis lupus familiaris | - |
- |
- |
| 3.4.21.27 | Didelphis sp. | - |
- |
- |
| 3.4.21.27 | Felis catus | - |
- |
- |
| 3.4.21.27 | Homo sapiens | P03951 | - |
- |
| 3.4.21.27 | Mus musculus | - |
- |
- |
| 3.4.21.27 | Ornithorhynchus anatinus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.27 | blood plasma | - |
Mus musculus | - |
| 3.4.21.27 | blood plasma | - |
Homo sapiens | - |
| 3.4.21.27 | kidney | - |
Homo sapiens | - |
| 3.4.21.27 | liver | - |
Mus musculus | - |
| 3.4.21.27 | liver | - |
Homo sapiens | - |
| 3.4.21.27 | pancreas | - |
Homo sapiens | - |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.21.27 | homodimer | 2 * 80000 | Mus musculus |
| 3.4.21.27 | homodimer | 2 * 80000 | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.27 | factor XI | - |
Mus musculus |
| 3.4.21.27 | factor XI | - |
Canis lupus familiaris |
| 3.4.21.27 | factor XI | - |
Felis catus |
| 3.4.21.27 | factor XI | - |
Ornithorhynchus anatinus |
| 3.4.21.27 | factor XI | - |
Didelphis sp. |
| 3.4.21.27 | factor XI | - |
Homo sapiens |
| 3.4.21.27 | FXI | - |
Mus musculus |
| 3.4.21.27 | FXI | - |
Canis lupus familiaris |
| 3.4.21.27 | FXI | - |
Felis catus |
| 3.4.21.27 | FXI | - |
Ornithorhynchus anatinus |
| 3.4.21.27 | FXI | - |
Didelphis sp. |
| 3.4.21.27 | FXI | - |
Homo sapiens |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 3.4.21.27 | Mus musculus | is predominantly, if not exclusively, expressed in the liver | up |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.21.27 | malfunction | addition of murine FXI to human FXI deficient plasma rescues the prolonged activated partial thromboplastin time, but with a slightly reduced activity compared with the human protein. FXI-/- mice are healthy, fertile, and phenotypically indistinguishable from wild-type animals. Mating between heterozygous FXI+/- mice follows the expected Mendelian ratio arguing against an association of FXI deficiency and increased risk of abortion. Plasma from FXI null mice show a severely prolonged activated partial thromboplastin time compared with wild-type animals. Bleeding times in adult FXI-/- mice are indistinguishable from wild-type animals, suggesting that FXI does not significantly contribute to fibrin formation. Formation of thrombi is severely defective in FXI-/- mice. Both fibrin deposition and platelet accumulation are reduced in FXI null mice compared with wild-type. FXI deficiency increases survival and reduces leukocyte infiltration and coagulopathy | Mus musculus |
| 3.4.21.27 | malfunction | FXI deficient humans suffer from mild hemorrhage (hemophilia C), which is characterized by trauma or soft tissue-related hemorrhage, primarily involving tissues with high fibrinolytic activity. Bleeding severity in FXI deficiency is not associated with FXI plasma levels. Addition of murine FXI to human FXI deficient plasma rescues the prolonged activated partial thromboplastin time, but with a slightly reduced activity compared with the human protein | Homo sapiens |
| 3.4.21.27 | malfunction | probably due to inbreeding, presence of FXI deficiency | Canis lupus familiaris |
| 3.4.21.27 | malfunction | probably due to inbreeding, presence of FXI deficiency | Felis catus |
| 3.4.21.27 | physiological function | 78% homology to human FXI at the protein level. FXI is critical for fibrin formation in vivo. FXI may have additional functions in regulation of inflammation or tissue repair distinct from its role in coagulation | Mus musculus |
| 3.4.21.27 | physiological function | presence of a single precursor of FXI and plasma kallikrein, appearance of FXI among early tetrapods | Ornithorhynchus anatinus |
| 3.4.21.27 | physiological function | the opossum genome has two distinct genes for both FXI and plasma kallikrein, indicating that the gene duplication event leading to separate factors occurred early in mammalian evolution | Didelphis sp. |
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