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Literature summary extracted from

  • Tumlin, J.A.; Roberts, B.R.; Kokko, K.E.; El Minshawy, O.; Gooch, J.L.
    T-cell receptor-stimulated calcineurin activity is inhibited in isolated T cells from transplant patients (2009), J. Pharmacol. Exp. Ther., 330, 602-607.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.16 additional information the enzyme is stimulated by the T-cell receptor Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.16 cyclosporin A
-
Homo sapiens
3.1.3.16 tacrolimus 27-30% inhibition at 5 ng/ml, females and males Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.16 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.16 T-lymphocyte
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.16 additional information
-
enzyme activity is much higher in mlaes compared to females, overview Homo sapiens
3.1.3.16 0.0000008 0.0000017 T-cells from females and males, not stimulated and T-cell-stimulated Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.16 a phosphoprotein + H2O
-
Homo sapiens dephosphorylated protein + phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.16 calcineurin
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.3.16 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.16 7.5
-
assay at Homo sapiens