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Literature summary extracted from

  • Fawcett, W.P.; Aracava, Y.; Adler, M.; Pereira, E.F.; Albuquerque, E.X.
    Acute toxicity of organophosphorus compounds in guinea pigs is sex- and age-dependent and cannot be solely accounted for by acetylcholinesterase inhibition (2009), J. Pharmacol. Exp. Ther., 328, 516-524.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 additional information acute toxicity of the nerve agents in guinea pigs is age- and sex-dependent and cannot be fully accounted for by the irreversible inhibition of AChE Cavia porcellus
3.1.1.7 O-isopropyl methylphosphonofluoridate i.e. sarin, a nerve agent, leads to irrversible inhibition of AChE Cavia porcellus
3.1.1.7 O-pinacolyl methylphosphonofluoridate i.e. soman, a nerve agent, leads to irrversible inhibition of AChE Cavia porcellus
3.1.1.7 S-[2-(diisopropylamino)ethyl]-O-ethylmethylphosphonothioate i.e. VX, a nerve agent, leads to irrversible inhibition of AChE Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Cavia porcellus
-
 male and female Hartley guinea pigs
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.7 blood
-
 Cavia porcellus
-
3.1.1.7 blood plasma
-
 Cavia porcellus
-
3.1.1.7 brain
-
 Cavia porcellus
-
3.1.1.7 erythrocyte
-
 Cavia porcellus
-

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 AChE
-
 Cavia porcellus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.7 37
-
 assay at Cavia porcellus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.7 7.4
-
 assay at Cavia porcellus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.7 0.0000029
-
 pH 7.4, 37°C Cavia porcellus O-pinacolyl methylphosphonofluoridate
3.1.1.7 0.00000338
-
 pH 7.4, 37°C Cavia porcellus S-[2-(diisopropylamino)ethyl]-O-ethylmethylphosphonothioate
3.1.1.7 0.00000727
-
 pH 7.4, 37°C Cavia porcellus O-isopropyl methylphosphonofluoridate