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Literature summary extracted from

  • Voolstra, O.; Oberhauser, V.; Sumser, E.; Meyer, N.E.; Maguire, M.E.; Huber, A.; von Lintig, J.
    NinaB is essential for Drosophila vision but induces retinal degeneration in opsin-deficient photoreceptors (2010), J. Biol. Chem., 285, 2130-2139.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.63 Drosophila melanogaster
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-
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1.13.11.65 Drosophila melanogaster Q9VFS2
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-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.63 eye expression is eye-dependent Drosophila melanogaster
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1.13.11.65 eye gene expression is eye-dependent and is activated as adownstream target of the eyeless/pax6 and sine oculis master control genes for eye development Drosophila melanogaster
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.63 zeaxanthin + O2
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Drosophila melanogaster (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal
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?
1.13.11.65 zeaxanthin + O2
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Drosophila melanogaster (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal beta-carotene is first converted to zeaxanthin and then cleaved by the enzmye to directly yield 3-hydroxy-retinal ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.63 NinaB
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Drosophila melanogaster
1.13.11.65 NinaB
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Drosophila melanogaster

Expression

EC Number Organism Comment Expression
1.13.11.65 Drosophila melanogaster gene expression is eye-dependent and is activated as a downstream target of the eyeless/pax6 and sine oculis master control genes for eye development up

General Information

EC Number General Information Comment Organism
1.13.11.65 physiological function mutants show no photophobic behavior indicating that NinaB is essential for larval light perception. Enzyme expression and chromophore production is governed by eyeless and so, major control genes for eye development Drosophila melanogaster
1.14.99.36 physiological function larvae of ninaB mutants show no photophobic behavior indicating that NinaB is essential for larval light perception. ninaB mutant flies exhibit impaired chromophore production and consequently lack visual pigments. Visual pigment production essentially depends on NinaB Drosophila melanogaster